Cntf MGI Mouse Gene Detail - MGI:88439 - ciliary neurotrophic factor

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Cntf Gene Detail
Summary
  • Symbol
    Cntf
  • Name
    ciliary neurotrophic factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88439
    NCBI Gene: 12803
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:12741024-12742996 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 8.73 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88439
protein coding gene Chr19:12740892-12742996 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024914
protein coding gene Chr19:10248471-10250443 (-)
A/J MGP_AJ_G0024890
protein coding gene Chr19:9600090-9602062 (-)
AKR/J MGP_AKRJ_G0024862
protein coding gene Chr19:10075258-10077230 (-)
BALB/cJ MGP_BALBcJ_G0024889
protein coding gene Chr19:9610738-9612710 (-)
C3H/HeJ MGP_C3HHeJ_G0024653
protein coding gene Chr19:9966066-9968038 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025338
protein coding gene Chr19:10797767-10799739 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022764
protein coding gene Chr19:10232872-10234846 (-)
CAST/EiJ MGP_CASTEiJ_G0024122
protein coding gene Chr19:9529468-9531439 (-)
CBA/J MGP_CBAJ_G0024627
protein coding gene Chr19:10895525-10897497 (-)
DBA/2J MGP_DBA2J_G0024759
protein coding gene Chr19:9659661-9661633 (-)
FVB/NJ MGP_FVBNJ_G0024722
protein coding gene Chr19:9665307-9667279 (-)
LP/J MGP_LPJ_G0024842
protein coding gene Chr19:10327336-10329308 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024749
protein coding gene Chr19:10659285-10661257 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025386
protein coding gene Chr19:10059134-10061106 (-)
PWK/PhJ MGP_PWKPhJ_G0023871
protein coding gene Chr19:9113052-9115020 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023675
protein coding gene Chr19:9218477-9220439 (-)
WSB/EiJ MGP_WSBEiJ_G0024190
protein coding gene Chr19:9915064-9917036 (-)



Homology
more
  • Human Ortholog
    CNTF, ciliary neurotrophic factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNTF, ciliary neurotrophic factor
  • Synonyms
    HCNTF
  • Links
    NCBI Gene ID: 1270
    UniProt: P26441

  • Chr Location
    11q12.1; chr11:58622665-58625733 (+) GRCh38
Human Diseases
more
  • Diseases
    5 with human CNTF associations

Human Disease Mouse Models
IDs
disease of mental health

DOID:150
ICD10CM:F99
MESH:D001523
NCI:C2893
UMLS_CUI:C0004936
IDs
glaucoma

DOID:1686
ICD10CM:H40
ICD9CM:365
ICD9CM:365.9
MESH:D005901
NCI:C26782
UMLS_CUI:C0017601
IDs
Huntington's disease

DOID:12858
ICD10CM:G10
ICD9CM_2006:333.4
ICD9CM:333.4
KEGG:05016
MESH:D006816
NCI:C82342
OMIM:143100
UMLS_CUI:C0020179
IDs
multiple sclerosis

DOID:2377
ICD10CM:G35
ICD9CM:340
MESH:D009103
NCI:C3243
OMIM:612594
OMIM:612595
OMIM:612596
UMLS_CUI:C0026769
IDs
obesity

DOID:9970
EFO:0001073
ICD10CM:E66.9
ICD9CM:278.00
MESH:D009765
NCI:C159658
OMIM:601665
UMLS_CUI:C0028754
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display progressive atrophy and degeneration of motor neurons in adulthood and reduced muscle strength. Another allele does not display any overt abnormalities at birth, however motor neuron sprouting does not occur after damage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
    7
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079415 Ensembl Gene Model | MGI Sequence Detail 1973 C57BL/6J ± kb
    transcript ENSMUST00000112933 Ensembl | MGI Sequence Detail 1073 Not Applicable
    polypeptide ENSMUSP00000108555 Ensembl | MGI Sequence Detail 198 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 10
      Primer pair 4
      Other 1
    Other
    Accession IDs
    less
    MGD-MRK-2043, MGI:2147531
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 19
      Gene Ontology 13
      Phenotypes 44
    • Earliest
      J:14942 Kaupmann K, et al., The gene for ciliary neurotrophic factor (CNTF) maps to murine Chromosome 19 and its expression is not affected in the hereditary motoneuron disease 'Wobbler' of the mouse. Eur J Neurosci. 1991;3:1182-86
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    TSS for Cntf:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr158446 Chr19:12742811-12742849 (-) 166 bp
    Tssr158445 Chr19:12742782-12742807 (-) 201 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support. last database update
    09/30/2025
    MGI 6.24 The Jackson Laboratory
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