The International Foundation for Optic Nerve Disease promotes research into the causes, prevention and treatment of optic nerve disease. We inform patients, families, clinicians, scientists and interested people about optic nerve disease.
For recent developments in optic nerve disease issues, see our news box. Our reference section links to informative articles, sites, authorities and institutions. The IFOND Dictionary is our referenced glossary of terms relevant to optic nerve disease.
See here to learn about contributing data to disease registries.
Please contact us if you would like to make suggestions, contributions, to Donate or to apply for research funding.
The optic nerve is the essential link between eye and brain that makes vision possible. If the optic nerve is seriously affected by disease or damaged through trauma or a tumor, visual loss or blindness may result.
The major optic nerve diseases are:
Glaucoma
Toxic Optic Nerve Disease
Ischemic Optic Neuropathy
Leber's Hereditary Optic Neuropathy (LHON)
Together, they affect millions of people worldwide. Optic nerve disease of other types are no less important for their impact on individuals and families and for understanding the mechanisms of optic nerve disease.
The understanding and definition of optic nerve disease began to change in the 1980's with a series of neuroscientific discoveries that helped explain the process by which nerve cells, including those in the optic nerve, die. One major cause of nerve cell death is an insufficient supply of energy which nerve cells derive from oxidative metabolism. By depriving optic nerve cells of energy they are prone to a destructive cascade of events which may kill them.
This discovery and related investigations of the mechanisms involved in nerve cell death, have broadened the understanding of how the optic nerve is damaged when it becomes diseased. It is now known that visual loss and blindness may result not only from physical insult (trauma) and decreased blood supply to the optic nerve, but also from disease that originates in the optic nerve itself.
The research in optic nerve disease is promising and exciting to scientists and physicians in many disciplines. They are now involved in research related to further understanding of optic nerve disease, prevention, and therapy. Therapies designed to protect the optic nerve from disease are being developed.
Our Projects section keeps you up to date in IFOND sponsored research.
Research in optic nerve disease is taking place in laboratories around the world. If you would like to contribute to this effort by volunteering or Donating, please contact IFOND. Your help may be of great assistance to the current search for therapies. Thank you for your interest!
Leber hereditary optic neuropathy, though the most common of all mitochondrial genetic diseases, is still relatively rare. Registering patients and genetic carriers in large numbers is very useful to allow adequate power in studies to progress our understanding of disease processes and guide therapies. Learn about registering patient and carrier data for research on LHON.
Efficient funding
IFOND is an extremely lean, all volunteer 501(c)(3) tax status registered nonprofit. We have no salaried associates. Our process minimizes costs and maximizes funding for researchers' direct, non administrative expenses. All donations are tax deductible in the United States of America. Our recent tax returns are searchable here e.g. latest IRS website listed year 2023 here. Tax Year 2022 Form 990EZ and Tax Year 2022 IRS Filing Acceptance. Also see here. Our strong scientific board includes many of the prominent world leading published researchers in optic neuropathies who plan, guide and do research in optic nerve disease. If this big bang for your buck, open disclosure model appeals to you, please donate. If you are a researcher in optic neuropathy, we welcome your funding application.
LHON IFOND research | LHON treatment prospects | Mitochondrial Genome Editing | LHON talks | Pay it forward | Mitochondrial Regulation | Avoid BAK eye drop preservative, etc. | We experiment with cigarette smoke so you need not. | Viral vector trials | EPI-743 LHON trials | Idebenone LHON treatment
Digests: NEI News | Mitochondrial Disease News LHON | ARVO Journals LHON | PubMed LHON | Europe PMC LHON | MRC-MBU newsLast edited: 27 August 2025
The International Foundation for
Optic Nerve Disease
P. O. Box 777, Cornwall NY 12518, USA.
Phone/Fax: (845)5348606
Email: ifond@aol.com
Web site:
https://www.ifond.org/
IFOND is registered service mark of
The International Foundation for Optic Nerve Disease, est. October 1995.
Copyright 1999-2025, International Foundation for
Optic Nerve Disease.
The information contained on this website should not be considered medical guidance or professional advice. IFOND is not responsible for errors or omissions in information provided on this site or actions resulting from its use. IFOND does not publish all information from all available sources on optic nerve disease. IFOND is not responsible for the validity of the studies or reviews nor is it an advocate of studies or reviews mentioned on or linked from the IFOND web site. IFOND does not endorse or recommend participation in any particular clinical trial or treatment protocol which may be mentioned on this site. Direct any questions concerning your personal health to your appropriate health care professional.