A Global Network - Functional Annotation of Animal Genomes (FAANG)

A coordinated international action to accelerate genome to phenome

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Since 2015, the FAANG consortium is working to discover basic functional knowledge of genome function to decipher the genotype-to-phenotype (G2P) link in farmed animals. Our community is working to

standardize core assays and experimental protocols,
coordinate and facilitate data sharing through its Data Portal, and
establish suitable infrastructures for data analysis.

We have described a set of research priorities for the next decade of FAANG research (FAANG to Fork strategy) to link G2P in diverse populations of animals and apply innovative new technologies to model G2P at the cell, tissue and whole animal scale.

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', BGCOLOR, '#FFFF99', FADEIN, 400, SHADOW, true, SHADOWCOLOR, '#9eaefe', WIDTH, 340, ABOVE, true, TITLE, 'In vitro systems')" onMouseOut="UnTip()">

... Technological development, coordination and standardisation by the DCC will continue to be crucial for the shift towards population scale studies, single-cell datasets, cell atlases and pangenomes', BGCOLOR, '#FFFF99', FADEIN, 400, SHADOW, true, SHADOWCOLOR, '#9eaefe', WIDTH, 340, ABOVE, true, TITLE, 'Large data collections')" onMouseOut="UnTip()">

... deconvolute transcriptional and regulatory complexity', BGCOLOR, '#FFFF99', FADEIN, 400, SHADOW, true, SHADOWCOLOR, '#9eaefe', WIDTH, 340, ABOVE, true, TITLE, 'FAANG-SingleCell')" onMouseOut="UnTip()">

... link genetic variation to genome function', BGCOLOR, '#FFFF99', FADEIN, 400, SHADOW, true, SHADOWCOLOR, '#9eaefe', WIDTH, 340, ABOVE, true, TITLE, 'FAANG-GTEx')" onMouseOut="UnTip()">

... capture all available population-level genomic information for a given species. Using graph-based frameworks, more accurately genotype and annotate the genomic diversity', BGCOLOR, '#FFFF99', FADEIN, 400, SHADOW, true, SHADOWCOLOR, '#9eaefe', WIDTH, 340, ABOVE, true, TITLE, 'Pangenomes')" onMouseOut="UnTip()">

... bridge the gaps between cell, tissue and whole animal scale knowledge', BGCOLOR, '#FFFF99', FADEIN, 400, SHADOW, true, SHADOWCOLOR, '#9eaefe', WIDTH, 340, ABOVE, true, TITLE, 'In vitro systems')" onMouseOut="UnTip()">

... meet the challenges to the global food system, which will need to produce more healthy food using fewer natural resources, reducing the environmental impact, conserving biodiversity and flexibly adjusting to changing societal expectations', BGCOLOR, '#FFFF99', FADEIN, 400, SHADOW, true, SHADOWCOLOR, '#9eaefe', WIDTH, 340, ABOVE, true, TITLE, 'Improved animals for a better world')" onMouseOut="UnTip()">

... CRISPR-mediated modification of putative genomic elements can confirm their functionality and reveal their roles in cellular (and organoid) function', BGCOLOR, '#FFFF99', FADEIN, 400, SHADOW, true, SHADOWCOLOR, '#9eaefe', WIDTH, 340, ABOVE, true, TITLE, 'Genome editing')" onMouseOut="UnTip()">

... alleviate the limitations on accurate predictions in genetically distant populations', BGCOLOR, '#FFFF99', FADEIN, 400, SHADOW, true, SHADOWCOLOR, '#9eaefe', WIDTH, 340, ABOVE, true, TITLE, 'Genomic selection')" onMouseOut="UnTip()">

... enhance prediction of adaptive capacity at the individual, farm or population level through integration of prior environmental data with individual genome information', BGCOLOR, '#FFFF99', FADEIN, 400, SHADOW, true, SHADOWCOLOR, '#9eaefe', WIDTH, 340, ABOVE, true, TITLE, 'Genome-enabled management')" onMouseOut="UnTip()">

... farm animal organoids will be valuable over the coming decade, providing information about fundamental biology to model the effects of changing environmental conditions and supporting immunology, vaccinology, physiology, nutritional and biodiversity', BGCOLOR, '#FFFF99', FADEIN, 400, SHADOW, true, SHADOWCOLOR, '#9eaefe', WIDTH, 340, ABOVE, true, TITLE, 'Fundamental biology')" onMouseOut="UnTip()">

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