When genes beat cheese

Google Trends is an amazing tool that can shed light on important historical trends relating to politics, religion, and society as a whole. It can also be used to see whether 'genes' has ever been a more popular search term than 'cheese'.

Looking across the whole corpus of Google Trends data (2004–present) it reveals — in the UK at least — that 'genes' came tantalisingly close to overtaking 'cheese' in popularity in 2007:

But wait! If we zoom in to that early part of 2007 we see that for a glorious week at the start of February that 'genes' was indeed a more popular search term than 'cheese'!

British genes for British people?

This historic victory for genetics seems to be a British phenomenon. Running the same search in other countries, or using the 'worldwide' dataset, doesn't reveal the same pattern. Here is what the genes vs cheese fight looks like in America:

Why?

I have described an important historic event but I am at a loss to explain why this trend emerged. The trend starts on January 30th 2007...I have searched Google for genes-related news around this time but nothing notable crops up. Any ideas?

Back from the dead...time for a new JABBA award!

I really wasn't intending to hand out any more JABBA awards. The last time I gave out an award for a bogus bioinformatics acronym was back in February 2016 and that was meant to be that.

However, I recently saw something that sent a shiver down my spine and I felt obliged to dust off the JABBA award one more time (for now anyway).

Let's get straight to the point. Published in bioarXiv is a new preprint:

Now don't get me wrong, I love burritos and I think it's kind of a fun name for a piece of software. I just happen to think that in this case it is a somewhat tenuous acronym. So how do you get to make BURRITO the name of your tool?

Browser Utility for Relating micRobiome Information on Taxonomy and functiOn

It's the inclusion of 'O' from 'functiOn' that gets me.I guess 'BURMITF' didn't have such a good ring to it.

What else is on the menu?

Note that BURRITO shouldn't be confused with the QIIME application controller code called burrito-fillings or the electronic lab notebook software for computational researchers known as Burrito.

Also, you get bonus points if you can use BURRITO with SALSA. Of course, if BURRITO doesn't work out for you, then maybe try TACO or...er, TACO.

How and why the Institute of Cancer Research are using their new Illumina NovaSeq

Image credit: The Institute of Cancer Research, London

Yesterday, the The Institute of Cancer Researchdisclaimer: that's where I work — published a new blog post where they spoke to Nik Matthews, Genomics Manager in the ICR’s Tumour Profiling Unit, about the Illumina NovaSeq sequencing platform.

It's a little more technical than some of the ICR 'Science Talk' blog posts that we usually publish which is why I thought I'd link to it here.

As someone who was started their PhD around the time the yeast genome was being finished I still am shocked by how far the world of DNA sequencing has come. This is something Nik refers to in his opening answer:

We can now produce data equivalent to the size of the original human genome project every six minutes, which is astonishing.

By comparison, the yeast genome project — an international collaboration involving many different labs — took over five years to sequence its genome...all 12 Mbp of it! Read the full blog post to find out more about how, and why, the ICR adopted the NovaSeq platform:

Bioinformatics blogs

I was surprised to see this blog featured in a recent list of the Top 75 Bioinformatics Blogs and Websites for Bioinformaticians.

Any list that includes this blog — which I barely ever update these days — feels a little bit dubious, especially when I'm listed above some genuinely useful blogs.

Anyway, there are many genuinely useful blogs on this list so I recommend having a look at it. I also made an attempt a few years at listing some of my own favourite bioinformatics blogs...a list which seems to remain relevant.

Illumina's new NovaSeq platform unveiled at The Institute of Cancer Research, London

Dr Nik Matthews, Genomics Manager in the ICR's Tumour Profiling Unit. Credit: ICR

It feels a bit strange to be using this blog to link to a news post at my current employer, but I'm happy to share the news that the ICR has become the first organisation in the UK to deploy Illumina's NovaSeq platform.

The ICR's Dr Chris Lord, Deputy Director of the Breast Cancer Now Research Centre, had this to say:

One key area we are keen to use the NovaSeq sequencer for is to discover new ways to select the best available treatment for each individual cancer patient’s specific disease.

If we can do this, we should be able to improve how a significant number of patients are treated. With the NovaSeq system, this kind of work is now feasible – this will be a real game-changer for a lot of the work across the ICR.

Read more in the full news article on the ICR website:

Slides from my exit seminar

This morning I gave my last presentation at UC Davis. My highly informal exit seminar was a great opportunity to reflect on some of the many projects I've been involved with over the last decade here at Davis. Thank you to all who came, and a special thanks to Ian Korf for his kind introduction.

I include the slides below, but note that some of these slides won't make much sense without the narration (and you also get to miss out on two embedded videos). There was some video recorded via the Periscope app, but I found out today that Periscope only keeps video around for 24 hours, so unfortunately if you didn't watch the video when you had the chance it is now lost.


2015年11月21日 12.34: Updated to reflect that Periscope video content is no longer available.

JABBA, ORCA, and more bad bioinformatics acronyms

JABBA awards — Just Another Bogus Bioinformatics Acronym — are my attempt to poke a little bit of fun at the crazy (and often nonsensical) acronyms and initialisms that are sometimes used in bioinformatics and genomics. When I first started handing out these awards in June 2013, I didn't realize that I was not alone in drawing attention to these unusual epithets.

http://orcacronyms.blogspot.com

ORCA is the Organization for Really Contrived Acronyms a fun blog set up by an old colleague of mine, Richard Edwards. ORCA sets out to highlight strange acronyms across many different disciplines, whereas my JABBA awards focus on bioinformatics. Occasionally, there is some overlap, and so I will point you to the latest ORCA post which details a particularly strange initialism for a bioinformatics database:

ADAN - prediction of protein-protein interAction of moDular domAiNs

Be sure to read Richard's thoughts on this name, as well as checking out some of the other great ORCA posts, including one of my favorites (GARFIELD).