Researcher Information
Assistant Professor HIROSHI Ishii
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Neuroanatomy
College and School Educational Field
Division of Medical Sciences, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Department of Neuroanatomy
Academic Background
【Academic background(Doctoral/Master's Degree)】
1994-1998 A.B., Tohoku University (Aeronautics & Astronautics) 2001-2005 M.D., Osaka University 2007-2011 Ph.D., Chiba University (Neuroscience) Doctor of Philosophy 2011 Completed
【Academic background(Bachelor's Degree)】
Osaka University 200503
【Degree】
Doctor of Medicine & Doctor of Philosophy
Career
Columbia University in the City of New York, The College of Physicians and Surgeons, The Columbia Center for Translational Immunology The Uehara Memorial Research Fellow (2013年09月01日-2015年07月31日)
Year & Month of Birth
Academic Society
Society for Neuroscience (USA)
The Japan Neuroscience Society
The Japanese Association of Anatomists
Award
○しろまるThe General Insurance Association of Japan, Research Grant for Treatment & Management of Traffic Accident (2016年09月16日)
○しろまるThe Uehara Memorial Foundation Research Fellowship (2014年03月11日)
○しろまるThe Yasuda Memorial Medical Foundation Research Fellow (2013年12月14日)
Specialities
Neuroimmunology, neurosurgery, and stem cell biology
Speciality Keywords
Evolution and neuro-regeneration, neuro-immune association; subarachnoid hemorrhage (SAH), cerebral vasospasm; spinal cord injury (SCI), unfolded protein response-induced inflammation, microglia
Research Themes
Elucidation of mechanism underlying pathophysiology of spinal cord injury in terms of unfolded stress response-induced inflammation.
Books
- ISHII, Hiroshi; YAMASHITA, Toshihide; Editorial board member: YUZAKI, Michisuke DOI:10.14931/bsd.489 Heat shock protein, Brain Science Dictionary The Japan Neuroscience Society, Brain Science Dictionary Editorial Borad 2012/02
Papers
- CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine. Hirata Y, Furuhashi K, Ishii H, Li HW, Pinho S, Ding L, Robson SC, Frenette PS, Fujisaki J Cell Stem Cell, Cell Press 22 3 445-453 2018年03月01日
- N-myc downstream-regulated gene 2 protects blood-brain barrier integrity following cerebral ischemia. Takarada-Iemata M, Yoshikawa A, Ta HM, Okitani N, Nishiuchi T, Aida Y, Kamide T, Hattori T, Ishii H, Tamatani T, Le TM, Roboon J, Kitao Y, Matsuyama T, Nakada M, Hori O. Glia, Wiley Online Library, Epub ahead of print. 北國新聞、QLifePro 医療ニュースで取り上げられた。 2018年02月24日
- Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis. Le TM, Takarada-Iemata M, Ta HM, Roboon J, Ishii H, Tamatani T, Kitao Y, Hattori T, Hori O. J Neurochem, The International Society for Neurochemistry, in press. 2018年02月19日
- CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously. Hattori T, Kaji M, Ishii H, Jureepon R, Takarada-Iemata M, Minh Ta H, Manh Le T, Konno A, Hirai H, Shiraishi Y, Ozaki N, Yamamoto Y, Okamoto H, Yokoyama S, Higashida H, Kitao Y, Hori O. Glia, Wiley Periodicals, Epub ahead of print. 北國新聞、Yahooニュース、中日新聞、QLifePro 医療ニュース、日本の研究.comで取り上げられた。 2017年03月13日
- Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis. Ta HM, Le TM, Ishii H, Takarada-Iemata M, Hattori T, Hashida K, Yamamoto Y, Mori K, Takahashi R, Kitao Y, Hori O. J Neurochem, The International Society for Neurochemistry, Epub ahead of print. 表紙を飾った。筆頭著者は第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会(2016年9月、福岡)にて優秀発表者賞を受賞した。 2016年07月18日
- MHC class I expression by donor hematopoietc stem cells is required to inhibit NK cell attack in allogeneic, but not syngeneic recipient mice. Hirata Y, Li H, Takahashi K, Ishii H, Sykes M, Fujisaki J. PLoS One, Public Library Science, e0141785 2015
- ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Ishii H, Tanabe S, Ueno M, Kubo T, Kayama H, Serada S, Fujimoto M, Takeda K, Naka T, and Yamashita T. Cell Death and Disease, Nature Publishing Group, 4:e710 2013年07月04日
- Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury. Ishii H, Jin X, Ueno M, Tanabe S, Kubo T, Serada S, Naka T, Yamashita T. Cell Death and Disease, Nature Publishing Group, 3:e363 2012年08月09日
- Temporal changes in cell marker expression and cellular infiltration in a controlled cortical impact model in adult male C57BL/6 mice. Jin X, Ishii H, Bai Z, Itokazu T, Yamashita T. PLoS One, Public Library Science, 7:e41892 2012年07月24日
- Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins. Ishii H, Kubo T, Kumanogoh A, Yamashita T. Biochem Biophys Res Commun, Elsevier, 402:168-172 2010年10月12日
- Evaluation of quality of life in patients receiving palliative care. Ishii H, Ikeoka K, Nakauchi C, Yamamoto M, Yano M, Yagi Y, Fujita H, Adachi T, Morimoto K, Mandai T. Quality of Life Journal, Japan Society for Quality of Life, 5(1):41-45 (Japanese) 2004
- QOL change in patients after renal transplantation. Ikeoka K, Ishii H, Nakauchi C, Yano M, Kakuta Y, Takahara S, Fujita H, Adachi K, Morimoto K, Mandai T. Quality of Life Journal, Japan Society for Quality of Life, 4:71-77 (Japanese) 2004
- QOL change after promotion of women's health with exercise therapy. Nakauchi C, Ishii H, Ikeoka K, Yano M, Shinagawa Y, Fujita H, Adachi T, Mandai T. Quality of Life Journal, Japan Society for Quality of Life, 5:47 (Japanese) 2004
Conference Presentations
- Transfer of Th1 cells promotes recovery from spinal cord injury. (conference:FASEB Summer Conference on Translational Neuroimmunology: From Mechanisms to Therapeutics, Carefree, Arizona, USA)(2012年07月31日)
- Implantation of Th1 cells ameliorates recovery after spinal cord injury. (conference:Neuro2010, The 33rd Annual Meeting of the Japan Neuroscience Society, Kobe, Japan)(2010年09月02日)
- Case study of herpes simplex encephalitis that developed with symptom of afebrile headache. (conference:Forum of Mie Medical Complex, Post Graduate Medical Training)(2007/01)
Others
Arts and Fieldwork
Patent
○しろまるCOMPOSITION FOR TREATING CENTRAL NERVE DAMAGE, AND USE THEREOF, WO125531 (publish date:2013年08月29日)
○しろまるComposition for Treating Central Nerve Damage, and use thereof. Pub. No. 2015-091761 Japan Patent (publish date:2015年05月14日)
Theme to the desired joint research
○しろまる1. Neuro-regeneration and immunology 2. Evolution and CNS diseases; I am skilled in analysis of the central nervous system using flow cytometry/cell sorter. I am look forward to collaborating with scientists/clinicians who are interested in similar theme to mine and, dedicated in or interested in live imaging with techniques such as multi-photon excitation microscopy.
Grant-in-Aid for Scientific Research
○しろまるFund for the Promotion of Joint International Research (Fostering Joint International Research (A))「Developing novel therapy for subarachnoid hemorrhage」(2018-2021)
○しろまるGrant-in-Aid for Scientific Research (C)「Elucidation of molecular mechanisms underlying vasospasm after subarachnoid hemorrhage.」(2017-2019)
○しろまるGrant-in-Aid for Young Scientists (Start-up)「Functions of adoptive immune system after injury of the central nervous system and immunomodulatory treatment」(2012-2013)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○しろまるFreshman Seminar I(2017)
○しろまるEmbryology(2017)
○しろまるNeuroanatomy(2017)
○しろまるNeuroanatomy(2016)
○しろまるHuman Embryology(2016)
Classes (Graduate Schools)
○しろまるPrinciples of Anatomy(2017)
○しろまるMolecular Targeting in the Central Nervous System(2017)
○しろまるMolecular Targeting in the Central Nervous System(2017)
○しろまるMolecular Targeting in the Central Nervous System(2016)
○しろまるMolecular Targeting in the Central Nervous System(2016)
○しろまるPrinciples of Anatomy(2016)