段旭君 (教授)

个人简介

段旭君,电子科技大学生命科学与技术学院教授,博士生导师。国家自然科学基金优青(2023);国际脑图谱年会(OHBM)Keynote Speaker(2023);中国图象图形学学会石青云女科学家奖(2024); 科技部重点研发计划青年科学家项目负责人(2024);四川省杰出青年基金(2024)。中国认知科学学会 儿童脑智发展与健康专业委员会 副主任委员;中国遗传学会 行为遗传分会 委员;中国神经科学学会 儿童认知与脑功能障碍分会 委员;中国自动化学会 智能健康与生物信息专委会 委员;中国图象图形学学会 视觉认知与计算专委会 委员;四川省神经科学学会 理事;国际脑影像期刊《Imaging Neuroscience》编委。

主要研究领域为孤独症脑影像,在孤独症脑动态网络成像、多模态融合成像、脑成像引导的神经调控等方面开展了一系列研究,建立了"评估-干预-成像"的孤独症智能诊疗平台,并开展临床应用,发起并成立中国孤独症脑影像联盟。相关研究成果以第一/通讯作者发表在PNAS, Biological Psychiatry,Science Bulletin,eLife等期刊;主持5项国家自然科学基金项目和1项科技部重点研发计划青年科学家项目(均为孤独症脑影像领域)。

主持或参与的科研项目

1. 国家重点研发计划青年科学家项目,2024YFF0509100,孤独症仿生光声刺激的神经反馈与调控研究,2024/12-2029/11,400万元,在研,主持

2. 国家自然科学基金优秀青年基金,82322035,孤独症脑成像,2024/01-2027/12, 200万元,主持

3. 广东省重点领域研发计划, 孤独症早期诊断及干预技术研究,2023B0303020001,2023/01-2025/12,500万元,在研,主持

4. 国家自然科学基金面上项目,62273076,多源融合的孤独症神经机制建模与辅助诊疗算法研究,2023/01-2026/12,53万元,在研,主持

5. 国家自然科学基金面上项目,81871432,经颅磁刺激干预儿童孤独症的多模态影像学神经机制研究,2019/01-2022/12, 56万元,已结题,主持

6. 国家自然科学基金面上项目,61673089,儿童孤独症早期干预的脑可塑性多模态磁共振研究,2017/01-2020/12, 62万元,已结题,主持

获奖

1.中国图象图形学学会石青云女科学家奖,段旭君,2024年,排名(1/1)

2. 磁共振脑网络成像新方法及其对癫痫脑机制的研究,四川省科学技术进步奖,自然科学类一等奖,2018,排名(5/5)

3.癫痫多模态磁共振成像新技术临床应用研究,中华人民共和国教育部,科技进步一等奖 2013年,排名(17/18)

专利

1.段旭君,李镭,肖金明,陈华富,基于磁共振成像的个体空间经颅磁刺激精准定位导航的方法。专利号:ZL 2022 1 0373878.4

2. 陈彦弛,段旭君,廖伟,刘宏宇,雷鑫峰,王润诗。一种基于杏仁核功能环路介导的重复经颅磁刺激影像导航的方法。2018,申请号:201810125830.5

3.廖伟,段旭君,陈华富。一种基于fMRI探测动态脑自发活动的数据方法。专利号:ZL 2016 1 0524807.4

软件著作权

1.段旭君,单晓龙,肖金明,何长春,陈华富。孤独症眼动评估软件。登记号:2020SR0295320。

2.龙治良,段旭君,廖伟,陈华富。基于神经影像亚分类软件。登记号:2020SR0347621。

3.陈华富,陈恒,何长春,郭肖楠,卢凤梅,段旭君。双聚类大脑皮下脑区亚区定位软件。登记号:2019SR0772808。

4.段旭君,李镭,陈华富,功能环路介导的深部脑刺激定位软件。登记号:2023SR0280008.

代表性论文:

2025

[1]Xinyue Huang, Weixing Zhao, Rui Feng, Yuanyue Zhou, Jia Wang, Jinming Xiao, Lei Li, Xiaolong Shan, Yu Feng, Yating Ming, Jing Cao, Xiaodong Kang, Lijie Wu, Huafu Chen*, Xujun Duan*. Linking gut microbiome profiles and white matter integrity to social behavior in young autistic children: from the perspective of individual variation. Science Bulletin, 2025, in press

[2]Jinming Xiao #, Yating Ming#, Lei Li #, Xinyue Huang, Yuanyue Zhou , Jianjun Ou , Juan Kou , Rui Feng , Rui Ma , Qingyu Zheng , Xiaolong Shan , Yao Meng , Wei Liao , Yingli Zhang , Ting Wang , Yangying Kuang, Jing Cao , Shijun Li , Hua Lai , Jia Chen , Qi Wang , Xiaoli Dong, Xiaodong Kang , Huafu Chen*, Vinod Menon *, Xujun Duan*. Personalized theta-burst stimulation enhances social skills in young minimally verbal children with autism: a double-blind randomized controlled trial. Biological Psychiatry, 2025, doi: 10.1016/j.biopsych.202501002.

[3]Xujun Duan*, Xiaolong Shan, Lucina Q. Uddin, Huafu Chen*. The future of disentangling the heterogeneity of autism with neuroimaging studies. Biological Psychiatry, Volume 97, Issue 5P428-438March 01, 2025 https://doi.org/10.1016/j.biopsych.202408008

[4]Lei Li, Jinming Xiao, Weixing Zhao, Qingyu Zheng, Xinyue Huang, Xiaolong Shan, Yating Ming, Peng Wang, Zhen Wu, Huafu Chen*, Vinod Menon*, Xujun Duan*. Mother-child dyadic interactions shape children’s social brain and theory of mind. eLife, 2025, https://doi.org/10.7554/eLife.103017.1

[5]Lei Li, Xinyue Huang, Qingyu Zheng, Jinming Xiao, Xiaolong Shan, Huafu Chen*, Xujun Duan*. Similarity or complementarity? Understanding marital relationships in terms of sexual dimorphism in brain morphometry and gender roles. NeuroImage, 2025年1月1日, 305: 120974

[6]Lei Li, Xinyue Huang, Qingyu Zheng, Jinming Xiao, Xiaolong Shan, Huafu Chen*, Xujun Duan*. Similar trajectories of psychological states predict marital satisfaction. Imaging Neuroscience. 2025年1月22日.

2024

[1]Weihua Zhao*, Keith M. Kendrick, Xujun Duan*. Challenges and prospects in the autism spectrum disorder field. Medicine Plus, 2024, 1, 100045

[2] Yu Feng, Xinyue Huang, Weixin Zhao, Yating Ming , Yuanyue Zhou, Rui Feng Jinming Xiao, Xiaolong Shan, Xiaodong Kang, Xujun Duan*, Huafu Chen*. Association among internalizing problems, white matter integrity, and social difficulties in children with autism spectrum disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 135, 20 December 2024, 111109

[3] Xiaolong Shan, · Peng Wang, · Qing Yin,· Youyi Li, · Xiaotian Wang, · Yu Feng,· Jinming Xiao, · Lei Li, ·Xinyue Huang, · Huafu Chen, · Xujun Duan, Atypical dynamic neural configuration in autism spectrum disorder and its relationship to gene expression profiles, European Child & Adolescent Psychiatry, 2024, Accepted

[4]Xinyue Huang, Leying Gao, Jiming Xiao, Lei Li, Xiaolong Shan, Huafu Chen, Xiaoqian Chai*, Xujun Duan*, Family environment modulates linkage of transdiagnostic psychiatric phenotypes and dissociable brain features in the developing brain, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2024, Accepted

[5]单晓龙,陈华富,段旭君*,孤独症谱系障碍多模态磁共振脑影像模式识别。心理科学进展,2024,vol. 32, No. 7

[6] Zhao W, Li L, Yang X, Wang X, Kou J, Chen J, Chen H, Wang Q, Duan X. Brain development of a school-aged boy with autism spectrum condition talented in arithmetic: a case report. Psychoradiology. 2024 Apr 18;4:kkae008. doi: 10.1093/psyrad/kkae008.

2023

[1]Xiaolong Shan, Lucina Q. Uddin, Rui Ma, Pengfei Xu, Jinming Xiao, Lei Li, Xinyue Huang, Yu Feng, Changchun He, Huafu Chen*, Xujun Duan*. Disentangling the individual-shared and individual-specific subspace of altered brain functional connectivity in autism spectrum disorder, Biological Psychiatry. DOI: 10.1016/j.biopsych.2023年09月01日2

[2]Xinyue Huang, Yating Ming, Weixing Zhao, Rui Feng, Yuanyue Zhou, Lijie Wu, Jia Wang, Jinming Xiao, Lei Li, Xiaolong Shan, Jing Cao, Xiaodong Kang, Huafu Chen*, Xujun Duan*. Developmental prediction modeling based on diffusion tensor imaging uncovering age-dependent heterogeneity in early childhood autistic brain, Molecular Autism, 2023,14:41.

[3] 郑清予,李镭,肖金明,陈华富,段旭君。孤独症谱系障碍默认网络与任务正激活网络交互的共激活模式研究,《中华精神科杂志 》,2023,56 (4) 56 (4): 284-291,DOI: 10.3760/cma.j.cn113661-20221009-00278

2022

[1]JinmingXiao, Lucina Q.Uddin, YaoMeng, LeiLi, LeyingGao, XiaolongShan, XinyueHuang, WeiLiao, HuafuChen*, XujunDuan*. A spatio-temporal decomposition framework for dynamic functional connectivity in the human brain. NeuroImage, 2022, doi.org/10.1016/j.neuroimage.2022.119618

[2] Lei Li, Xinyue Huang, Jinming Xiao, Qingyu Zheng, Xiaolong Shan, Changchun He, Wei Liao, Huafu Chen*, Vinod Menon*, Xujun Duan*. Neural synchronization predicts marital satisfaction. Proc. Natl. Acad. Sci. U.S.A., 2022, 119 (34), e2202515119.

[3] Lei Li#, Xiaoran Su#, Qingyu Zheng, Jinming Xiao, XinYue Huang, Wan Chen, Kaihua Yang, Lei Nie, Xin Yang, Huafu Chen*, Shengli Shi*, Xujun Duan*.Cofluctuation analysis reveals aberrant default mode network patterns in adolescents and youths with autism spectrum disorder. Human Brain Mapping, 2022, DOI: 10.1002/hbm.25986.

[4] Xiaolong Shan, Lucina Q. Uddin, Jinming Xiao, Changchun He, Zihan Ling, Lei Li, Xinyue Huang, Huafu Chen, Xujun Duan*. Mapping the heterogeneous brain structural phenotype of autsim spectrum disorder using the normative model. Biological Psychiatry. 2022, 91:967–976.

2021

[1]Xinyue Huang, Lei Li, Zihan Ling, Leying Gao, Huafu Chen, Xujun Duan*. Gut microbiome diversity mediates the association between right dorsolateral prefrontal cortex and anxiety level. Brain Image and Behavior, 2021, Accepted.

[2]Heng Chen#, Fengmei Lu#, Fengmei Lu, Yajing Pang, Yajing Pang, Shaoqiang Han, Xujun Duan*, Huafu Chen*. Dimensional Analysis of Atypical Functional Connectivity of Major Depression Disorder and Bipolar Disorder. Cerebral Cortex, 2021, in press. https://doi.org/10.1093/cercor/bhab296

[3]Changchun He, Jesus M. Cortes, Xiaodong Kang, Jing Cao, Heng Chen, Xiaonan Guo, Ruishi Wang, Lingyin Kong, Xinyue Huang, Jinming Xiao, Xiaolong shan, Rui Feng, Huafu Chen, Xujun Duan*. Individual-based morphological brain network organization and its association with autistic symptoms in young children with autism spectrum disorder. Human Brain Mapping, 2021, 42(10):3282-3294.

[4]Jinming Xiao, Huafu Chen*, Xiaolong Shan, Changchun He, Ya Li, Xiaonan Guo, Heng Chen, Wei Liao, Lucina Q. Uddin*, Xujun Duan*. Linked social–communication dimensions and connectivity in functional brain networks in autism spectrum disorder. Cerebral Cortex, 2021, 31(8):3899-3910. DOI: 10.1093/cercor/bhab057

[5]Xiaonan Guo, Xujun Duan*,John Suckling, JiaWang, Xiaodong Kang, Heng Chen, Bharat B. Biswal, Jing Cao, Changchun He, Jinming Xiao, Xinyue Huang, Runshi Wang, Shaoqiang Han, Yun-Shuang Fan, Jing Guo, Jingping Zhao, Lijie Wu* and Huafu Chen*, Mapping progressive gray matter alterations in early childhood autistic brain. Cerebral Cortex, 2021,31(3):1500-1510.

[6]Xujun Duan#, Changchun He#, Jianjun Ou, Runshi Wang, Jinming Xiao, Lei Li, Renrong Wu, Yan Zhang*, Jingping Zhao*, Huafu Chen*. Reduced hippocampal volume and its relationship with verbal memory and negative symptoms in treatment-naive first-episode adolescent-onset schizophrenia. Schizophrenia Bulletin, 2021, 47(1): 64-74.

2020

[7]Lei Li, Changchun He, Taorong Jian, Xiaonan Guo, Jinming Xiao, Ya Li, Heng Chen, Xiaodong Kang, Huafu Chen, Xujun Duan*. Attenuated link between the medial prefrontal cortex and the amygdala in children with autism spectrum disorder: evidence from effective connectivity within the "social brain". Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 111:110147. doi: 10.1016/j.pnpbp.2020.110147

[8]Xujun Duan#, Maolin Hu#, Xinyue Huang, Chan Su, Xiaofen Zong, Xia Dong, Changchun He, Jinming Xiao, Haoru Li, Jinsong Tang*, Xiaogang Chen*, Huafu Chen*. Effect of risperidone monotherapy on dynamic functional connectivity of insular subdivisions in treatment-naive, first-episode schizophrenia. Schizophrenia Bulletin, 2020, 46(3): 650-660.

[9]Changchun He, Huafu Chen*, Lucina Q. Uddin, Asier Erramuzpe, Paolo Bonifazi, Xiaonan Guo, Jinming Xiao, Heng Chen, Xinyue Huang, Lei Li, Wei Sheng, Wei Liao, Jesus M. Cortes*, Xujun Duan*. Structure-Function Connectomics Reveals Aberrant Developmental Trajectory Occurring at Pre-adolescence in the Autistic Brain.Cerebral Cortex, 2020, 30(9):5028-5037.

[10] Xiaonan Guo, Xujun Duan*, Heng Chen, Changchun He, Jinming Xiao, Shaoqiang Han, Yun-Shuang Fan, Jing Guo, Huafu Chen*. Altered inter- and intrahemispheric functional connectivity dynamics in autistic children. Human Brain Mapping, 2020, 41 (2), 419-428

[11] Xujun Duan, Runshi Wang, Jinming Xiao, Ya Li, Xinyue Huang, Xiaonan Guo, Jing Cao, Liyao He, Changchun He, Zihan Ling, Xiaolong Shan, Heng Chen, Xiaodong Kang*, Huafu Chen*. Subcortical structural covariance in young children with autism spectrum disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 99:109874. DOI: 10.1016/j.pnpbp.2020.109874

[12] Xujun Duan#, Maolin Hu#, Xinyue Huang, Xia Dong, Xiaofen Zong, Changchun He, Jinming Xiao, Jinsong Tang*, Xiaogang Chen*, Huafu Chen*. Effects of risperidone monotherapy on the default-mode network in antipsychotic-naïve first-episode schizophrenia: Posteromedial cortex heterogeneity and relationship with the symptom improvements. Schizophrenia Research, 2020, 218:201-208. DOI: 10.1016/j.schres.202001001

2019

[13] Heng Chen, Lucina Q. Uddin, Xiaonan Guo, Jia Wang, Xiaomin Wang, Xujun Duan*, Huafu Chen*. Parsing brain structural heterogeneity in autism spectrum disorder reveals distinct clinical subtypes. Human Brain Mapping, 2019, 40(2): 628-637.

[14] Xiaonan Guo, Xujun Duan*, John Suckling, Heng Chen, Wei Liao, Qian Cui, Huafu Chen*. Partially impaired functional connectivity states between right anterior insula and default mode network in autism spectrum disorder, Human Brain Mapping, 2019, 40(4):1264-1275.

2018

[15] Heng Chen#, Jia Wang#, Lucina Q. Uddin, Xiaomin Wang, Xiaonan Guo, Fengmei Lu. Xujun Duan*, Lijie Wu*, Huafu Chen*. Aberrant functional connectivity of neural circuits associated with social and sensorimotor deficits in young children with autism spectrum disorder, Autism Research. 2018,11(2):1643-1652.

[16] Changchun He, Yanchi Chen, Taorong Jian, Heng Chen, Xiaonan Guo, Jia Wang, Lijie Wu*, Huafu Chen*, and Xujun Duan*. Dynamic functional connectivity analysis reveals decreased variability of the default-mode network in developing autistic brain. Autism Research, 2018. 11(11): 1479-1493.

教育经历

电子科技大学 工学学士学位

电子科技大学 工学博士学位

工作经历

2021.1-至今

电子科技大学生命科学与技术学院 | 研究员 | 研究员

2014.7-至今

电子科技大学生命科学与技术学院 | 副教授

2013.7-2014.6

电子科技大学生命科学与技术学院 | 讲师