Reactome Pathway Database

Schema > Reaction > Entries

DHTKD1 dimer decarboxylates 2-OA Show undefined attributes

catalystActivity

[CatalystActivity:10534805] oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor of OADH complex [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10534807

displayName DHTKD1 dimer decarboxylates 2-OA

eventOf

[Pathway:R-SSC-9858328] OADH complex synthesizes glutaryl-CoA from 2-OA - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SSC-9858590] DLST transfers glutaryl to CoA - Sus scrofa

inferredFrom

[Reaction:R-HSA-9858321] DHTKD1 dimer decarboxylates 2-OA - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

DHTKD1 dimer decarboxylates 2-OA
2-oxoadipate + H(+) + N(6)-((R)-lipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase) => CO2 + N(6)-((R)-S(8)-glutaryldihydrolipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase)

output

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-9858321

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-9858328] OADH complex synthesizes glutaryl-CoA from 2-OA

(precedingEvent)

[Reaction:R-SSC-9858590] DLST transfers glutaryl to CoA

(inferredTo)

[Reaction:R-HSA-9858321] DHTKD1 dimer decarboxylates 2-OA

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