Reactome Pathway Database

Schema > Reaction > Entries

acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ Show undefined attributes

catalystActivity

[CatalystActivity:10429272] 3-hydroxybutyrate dehydrogenase activity of BDH1 tetramer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10429274

displayName acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+

eventOf

[Pathway:R-SSC-77111] Synthesis of Ketone Bodies - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+
Reduction of Acetoacetate to beta-Hydroxybutyrate

output

precedingEvent

[Reaction:R-SSC-74180] HMG CoA => acetoacetic acid + acetyl CoA - Sus scrofa

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-73912

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-77111] Synthesis of Ketone Bodies

(inferredTo)

[Reaction:R-HSA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+

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