Reactome Pathway Database

Schema > Pathway > Entries

Urea cycle Show undefined attributes

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10537391

displayName Urea cycle

eventOf

[Pathway:R-SSC-71291] Metabolism of amino acids and derivatives - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:20612] urea cycle

hasDiagram true

hasEHLD false

hasEvent

[Reaction:R-SSC-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Sus scrofa
[Reaction:R-SSC-70555] 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] - Sus scrofa
[Reaction:R-SSC-70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate - Sus scrofa
[Reaction:R-SSC-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Sus scrofa
[Reaction:R-SSC-70573] argininosuccinate <=> fumarate + arginine - Sus scrofa
[Reaction:R-SSC-70569] arginine + H2O => ornithine + urea [ARG1] - Sus scrofa
[Reaction:R-SSC-452036] arginine + H2O => ornithine + urea [ARG2] - Sus scrofa
[Reaction:R-SSC-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Sus scrofa

inferredFrom

[Pathway:R-HSA-70635] Urea cycle - Homo sapiens

isInDisease false

isInferred true

maxDepth 2

name

Urea cycle
Urea synthesis

releaseDate 2025年09月18日

schemaClass Pathway

species

[Species:49633] Sus scrofa

stId R-SSC-70635

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-71291] Metabolism of amino acids and derivatives

(inferredTo)

[Pathway:R-HSA-70635] Urea cycle

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