Reactome Pathway Database

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DLD dimer dehydrogenates dihydrolipoyl Show undefined attributes

catalystActivity

[CatalystActivity:11020661] dihydrolipoyl dehydrogenase (NADH) activity of OGDH complex [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:11001822] Weiser, Joel, 2025年08月28日

dbId 11030305

displayName DLD dimer dehydrogenates dihydrolipoyl

eventOf

[Pathway:R-SPO-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Schizosaccharomyces pombe

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SPO-71401] OGDH dimer decarboxylates 2-OG - Schizosaccharomyces pombe

inferredFrom

[Reaction:R-HSA-9853499] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

DLD dimer dehydrogenates dihydrolipoyl
N(6)-((R)-dihydrolipoyl)-L-lysyl-(protein) + NAD(+) => H(+) + N(6)-((R)-lipoyl)-L-lysyl-(protein) + NADH

output

precedingEvent

[Reaction:R-SPO-9853512] DLST transfers succinyl to CoA - Schizosaccharomyces pombe

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68324] Schizosaccharomyces pombe

stId R-SPO-9853499

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SPO-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG

(precedingEvent)

[Reaction:R-SPO-71401] OGDH dimer decarboxylates 2-OG

(inferredTo)

[Reaction:R-HSA-9853499] DLD dimer dehydrogenates dihydrolipoyl

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