Reactome Pathway Database

Schema > Reaction > Entries

MDH2 dimer dehydrogenates MAL Show undefined attributes

catalystActivity

[CatalystActivity:11003173] L-malate dehydrogenase (NAD+) activity of MDH2 dimer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:11001822] Weiser, Joel, 2025年08月28日

dbId 11003175

displayName MDH2 dimer dehydrogenates MAL

eventOf

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

inferredFrom

[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

MDH2 dimer dehydrogenates MAL
(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate

output

precedingEvent

[Reaction:R-SPO-70982] FH tetramer hydrates fumarate to L-malate - Schizosaccharomyces pombe

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68324] Schizosaccharomyces pombe

stId R-SPO-70979

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(precedingEvent)

(inferredTo)

[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL

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