Reactome Pathway Database

Schema > Reaction > Entries

MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF Show undefined attributes

catalystActivity

[CatalystActivity:11023802] methenyltetrahydrofolate cyclohydrolase activity of MTHFD2, D2L [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:11001822] Weiser, Joel, 2025年08月28日

dbId 11023804

displayName MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF

eventOf

[Pathway:R-SPO-196757] Metabolism of folate and pterines - Schizosaccharomyces pombe

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SPO-6801462] MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF - Schizosaccharomyces pombe

inferredFrom

[Reaction:R-HSA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF

output

precedingEvent

[Reaction:R-SPO-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Schizosaccharomyces pombe

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68324] Schizosaccharomyces pombe

stId R-SPO-6801328

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SPO-196757] Metabolism of folate and pterines

(precedingEvent)

[Reaction:R-SPO-6801462] MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF

(inferredTo)

[Reaction:R-HSA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF

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