Reactome Pathway Database

Schema > Reaction > Entries

uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ Show undefined attributes

catalystActivity

[CatalystActivity:10088965] dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10088967

displayName uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+

eventOf

[Pathway:R-RNO-73621] Pyrimidine catabolism - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-RNO-73589] 5,6-dihydrouracil + H2O => beta-ureidopropionate - Rattus norvegicus

inferredFrom

[Reaction:R-HSA-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+
reduction of uracil to form dihydrouracil

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-73585

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-RNO-73621] Pyrimidine catabolism

(precedingEvent)

[Reaction:R-RNO-73589] 5,6-dihydrouracil + H2O => beta-ureidopropionate

(inferredTo)

[Reaction:R-HSA-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+

© 2025 Reactome

Cite Us!