Reactome Pathway Database

Schema > Reaction > Entries

ALK binds ligand midkine (MDK) Show undefined attributes

category binding

compartment

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10072480

displayName ALK binds ligand midkine (MDK)

eventOf

[Pathway:R-MMU-9851151] MDK and PTN in ALK signaling - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-MMU-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs - Mus musculus

inferredFrom

[Reaction:R-HSA-9667914] ALK binds ligand midkine (MDK) - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

ALK binds ligand midkine (MDK)

output

[Complex:R-MMU-9667909] MDK:ALK [plasma membrane]

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-9667914

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-9851151] MDK and PTN in ALK signaling

(precedingEvent)

[Reaction:R-MMU-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs

(inferredTo)

[Reaction:R-HSA-9667914] ALK binds ligand midkine (MDK)

© 2025 Reactome

Cite Us!