Reactome Pathway Database

Schema > Reaction > Entries

AMT transfers NH2CH2 from GCSH:SAMDLL to THF Show undefined attributes

catalystActivity

[CatalystActivity:10046142] aminomethyltransferase activity of AMT [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10046144

displayName AMT transfers NH2CH2 from GCSH:SAMDLL to THF

eventOf

[Pathway:R-MMU-6783984] Glycine degradation - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-MMU-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Mus musculus

inferredFrom

[Reaction:R-HSA-5693977] AMT transfers NH2CH2 from GCSH:SAMDLL to THF - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

AMT transfers NH2CH2 from GCSH:SAMDLL to THF
(6S)-5,6,7,8-tetrahydrofolate + N(6)-((R)-S(8)-aminomethyldihydrolipoyl)-L-lysyl-(protein) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + N(6)-((R)-dihydrolipoyl)-L-lysyl-(protein) + NH4(+)
AMT degrades GCSH:SAMDLL to GCSH:DHLL

output

precedingEvent

[Reaction:R-MMU-5693967] PXLP-K754-GLDC dimer decarboxylates Gly - Mus musculus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-5693977

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-6783984] Glycine degradation

(inferredTo)

[Reaction:R-HSA-5693977] AMT transfers NH2CH2 from GCSH:SAMDLL to THF

(precedingEvent)

[Reaction:R-MMU-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate

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