Reactome | Synthesis of pyrophosphates in the cytosol

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10082974

displayName Synthesis of pyrophosphates in the cytosol

eventOf

[Pathway:R-MMU-1483249] Inositol phosphate metabolism - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:258976] inositol phosphate metabolic process

hasDiagram false

hasEHLD false

hasEvent

[Reaction:R-MMU-1855219] I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol - Mus musculus
[Reaction:R-MMU-1855162] I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol - Mus musculus
[Reaction:R-MMU-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Mus musculus
[Reaction:R-MMU-1855223] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol - Mus musculus
[Reaction:R-MMU-1855166] PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol - Mus musculus
[Reaction:R-MMU-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Mus musculus
[Reaction:R-MMU-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Mus musculus
[Reaction:R-MMU-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Mus musculus
[Reaction:R-MMU-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Mus musculus
[Reaction:R-MMU-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Mus musculus
[Reaction:R-MMU-1855158] 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol - Mus musculus
[Reaction:R-MMU-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Mus musculus
[Reaction:R-MMU-1855165] (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol - Mus musculus
[Reaction:R-MMU-1855194] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol - Mus musculus
[Reaction:R-MMU-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Mus musculus

inferredFrom

[Pathway:R-HSA-1855167] Synthesis of pyrophosphates in the cytosol - Homo sapiens

isInDisease false

isInferred true

maxDepth 2

name

Synthesis of pyrophosphates in the cytosol

releaseDate 2025年09月18日

schemaClass Pathway

species

[Species:48892] Mus musculus

stId R-MMU-1855167

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

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Reactome Pathway Database

Synthesis of pyrophosphates in the cytosol Show undefined attributes

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