Reactome Pathway Database

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benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate Show undefined attributes

catalystActivity

[CatalystActivity:9976005] CoA-ligase activity of xenobiotic/medium-chain fatty acid:CoA ligases [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 9976007

displayName benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate

eventOf

[Pathway:R-MMU-177135] Conjugation of benzoate with glycine - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-MMU-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A - Mus musculus

inferredFrom

[Reaction:R-HSA-159443] benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate
Benzoate and Coenzyme A react to form benzoyl-CoA thioester

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-159443

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-177135] Conjugation of benzoate with glycine

(precedingEvent)

[Reaction:R-MMU-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A

(inferredTo)

[Reaction:R-HSA-159443] benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate

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