Reactome | MDK and PTN in ALK signaling

authored

[InstanceEdit:9851210] Rothfels, Karen, 2023年10月14日

created [InstanceEdit:9851150] Rothfels, Karen, 2023年10月12日

dbId 9851151

displayName MDK and PTN in ALK signaling

edited

[InstanceEdit:9851215] Rothfels, Karen, 2023年10月14日

eventOf

[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens

hasDiagram false

hasEHLD false

hasEvent

isInDisease false

isInferred false

literatureReference

[LiteratureReference:201494] Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin
[LiteratureReference:9667900] Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
[LiteratureReference:9667906] ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers
[LiteratureReference:9667871] The midkine family of growth factors: diverse roles in nervous system formation and maintenance
[LiteratureReference:9667877] Targeting midkine and pleiotrophin signalling pathways in addiction and neurodegenerative disorders: recent progress and perspectives
[LiteratureReference:9842807] In contrast to agonist monoclonal antibodies, both C-terminal truncated form and full length form of Pleiotrophin failed to activate vertebrate ALK (anaplastic lymphoma kinase)?
[LiteratureReference:9842748] Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin
[LiteratureReference:9843013] Expression and functional analysis of the anaplastic lymphoma kinase (ALK) gene in tumor cell lines
[LiteratureReference:9724079] Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines
[LiteratureReference:9842437] Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome
[LiteratureReference:9842539] FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase
[LiteratureReference:9842433] Augmentor ? and ? (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions
[LiteratureReference:9842490] Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-?)

maxDepth 2

modified [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

name

MDK and PTN in ALK signaling

orthologousEvent

releaseDate 2023年12月06日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9852935] Turner, Suzanne, 2023年11月08日

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-9851151

summation

[Summation:9850819] The cytokines pleiotrophin (PTN) and midikine (MDK) were ini...

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