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Go!
Schema
>
EntityWithAccessionedSequence
>
Entries
PLCG2 [cytosol]
Show undefined attributes
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compartment
[Compartment:70101] cytosol
componentOf
[Complex:R-HSA-5621157] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] - Homo sapiens
[Complex:R-HSA-9606886] p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] - Homo sapiens
consumedByEvent
[Reaction:R-HSA-5621356] PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G - Homo sapiens
[Reaction:R-HSA-9606894] p-DAPP1 (p-BAM32) binds PLCG2 - Homo sapiens
[Reaction:R-HSA-5607745] 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG - Homo sapiens
[BlackBoxEvent:R-HSA-9680348] PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated - Homo sapiens
[Reaction:R-HSA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Homo sapiens
created
[InstanceEdit:984801] May, B, 2010年11月03日
dbId
984806
deleted
[Deleted:9763706] Deletion of instance: 1604645
displayName
PLCG2 [cytosol]
endCoordinate
1265
inDisease
false
inferredTo
[EntityWithAccessionedSequence:R-MMU-5607628] Plcg2 [cytosol] - Mus musculus
[EntityWithAccessionedSequence:R-RNO-984806] Plcg2 [cytosol] - Rattus norvegicus
[EntityWithAccessionedSequence:R-CFA-984806] PLCG2 [cytosol] - Canis familiaris
[EntityWithAccessionedSequence:R-BTA-984806] PLCG2 [cytosol] - Bos taurus
[EntityWithAccessionedSequence:R-SSC-984806] PLCG2 [cytosol] - Sus scrofa
[EntityWithAccessionedSequence:R-XTR-984806] plcg2 [cytosol] - Xenopus tropicalis
[EntityWithAccessionedSequence:R-GGA-984806] PLCG2 [cytosol] - Gallus gallus
[EntityWithAccessionedSequence:R-DME-984806] sl [cytosol] - Drosophila melanogaster
[EntityWithAccessionedSequence:R-DDI-984806] PLCG2 [cytosol] - Dictyostelium discoideum
[EntityWithAccessionedSequence:R-SPO-984806] PLCG2 [cytosol] - Schizosaccharomyces pombe
[EntityWithAccessionedSequence:R-SCE-984806] PLCG2 [cytosol] - Saccharomyces cerevisiae
[EntityWithAccessionedSequence:R-PFA-984806] PLCG2 [cytosol] - Plasmodium falciparum
literatureReference
[LiteratureReference:984795] Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor
maxDepth
1
memberOf
[DefinedSet:R-HSA-1169089] PLC gamma1,2 [cytosol] - Homo sapiens
modified
[InstanceEdit:3632907] Wu, G, 2013年05月28日
name
PLCG2
Phospholipase C gamma 2
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
PLCG2_HUMAN
positivelyRegulates
[PositiveRegulation:R-HSA-2201314] Positive regulation by 'PLCG2 [cytosol]'
referenceEntity
[ReferenceGeneProduct:uniprot:P16885] UniProt:P16885 PLCG2
referenceType
ReferenceGeneProduct
schemaClass
EntityWithAccessionedSequence
species
[Species:48887] Homo sapiens
stId
R-HSA-984806
startCoordinate
1
Referrals
(replacementInstances)
[Deleted:9763706] Deletion of instance: 1604645
(input)
[BlackBoxEvent:R-HSA-9680348] PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated
[Reaction:R-HSA-5621356] PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G
[Reaction:R-HSA-9606894] p-DAPP1 (p-BAM32) binds PLCG2
[Reaction:R-HSA-5607745] 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
[Reaction:R-HSA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
(regulator)
[PositiveRegulation:R-HSA-2201314] Positive regulation by 'PLCG2 [cytosol]'
(hasComponent)
[Complex:R-HSA-5621157] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane]
[Complex:R-HSA-9606886] p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane]
[Complex:R-HSA-9606170] PLCG2:PIP3 [plasma membrane]
(hasMember)
[DefinedSet:R-HSA-1169089] PLC gamma1,2 [cytosol]
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