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Schema
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BlackBoxEvent
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Entries
CLPXP degrades mitochondrial matrix proteins
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authored
[InstanceEdit:9838119] May, Bruce, 2023年06月21日
catalystActivity
[CatalystActivity:9839056] ATP-dependent peptidase activity of CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix]
category
uncertain
compartment
[Compartment:5460] mitochondrial matrix
created
[InstanceEdit:9838283] May, Bruce, 2023年06月22日
dbId
9838289
displayName
CLPXP degrades mitochondrial matrix proteins
edited
[InstanceEdit:9838119] May, Bruce, 2023年06月21日
eventOf
[Pathway:R-HSA-9837999] Mitochondrial protein degradation - Homo sapiens
input
[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix]
[Complex:R-HSA-9838070] CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix]
[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9838048] LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival
[LiteratureReference:9838056] Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP
[LiteratureReference:9838293] Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX
[LiteratureReference:9838344] Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP
[LiteratureReference:9838274] Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis
[LiteratureReference:9838316] Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX
[LiteratureReference:9839690] Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
CLPXP degrades mitochondrial matrix proteins
orthologousEvent
[BlackBoxEvent:R-CEL-9838289] CLPXP degrades mitochondrial matrix proteins - Caenorhabditis elegans
[BlackBoxEvent:R-DME-9838289] CLPXP degrades mitochondrial matrix proteins - Drosophila melanogaster
[BlackBoxEvent:R-XTR-9838289] CLPXP degrades mitochondrial matrix proteins - Xenopus tropicalis
[BlackBoxEvent:R-SSC-9838289] CLPXP degrades mitochondrial matrix proteins - Sus scrofa
[BlackBoxEvent:R-BTA-9838289] CLPXP degrades mitochondrial matrix proteins - Bos taurus
[BlackBoxEvent:R-CFA-9838289] CLPXP degrades mitochondrial matrix proteins - Canis familiaris
[BlackBoxEvent:R-RNO-9838289] CLPXP degrades mitochondrial matrix proteins - Rattus norvegicus
[BlackBoxEvent:R-MMU-9838289] CLPXP degrades mitochondrial matrix proteins - Mus musculus
output
[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix]
[Complex:R-HSA-9838085] CLPXP [mitochondrial matrix]
[SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-9838035] CLPXP binds mitochondrial matrix proteins - Homo sapiens
releaseDate
2023年12月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9852695] Aljghami, Mazen E, 2023年11月04日
[InstanceEdit:9852696] Houry, Walid A, 2023年11月04日
[InstanceEdit:9852693] Morey, Trevor, 2023年11月04日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9838289
summation
[Summation:9838318] The CLPXP complex comprises two heptameric rings of the barr...
Referrals
(hasEvent)
[Pathway:R-HSA-9837999] Mitochondrial protein degradation
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