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Schema
>
Reaction
>
Entries
Ligand-independent dimerization of KIT extracellular domain mutants
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authored
[InstanceEdit:9680211] Rothfels, Karen, 2020年03月25日
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9680243] Rothfels, Karen, 2020年03月26日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9680242
disease
[Disease:1500689] cancer
displayName
Ligand-independent dimerization of KIT extracellular domain mutants
edited
[InstanceEdit:9686618] Rothfels, Karen, 2020年05月04日
entityFunctionalStatus
[EntityFunctionalStatus:9680254] gain_of_function of extracellular domain mutants of KIT [plasma membrane]
eventOf
[Pathway:R-HSA-9680187] Signaling by extracellular domain mutants of KIT - Homo sapiens
followingEvent
[Reaction:R-HSA-9680248] Phosphorylation of extracellular domain KIT mutants - Homo sapiens
input
2 ×
[CandidateSet:R-HSA-9680195] extracellular domain mutants of KIT [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9679981] Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations
[LiteratureReference:9679992] Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate
[LiteratureReference:1433334] Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor
[LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications
[LiteratureReference:9673518] Gastrointestinal stromal tumours: origin and molecular oncology
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Ligand-independent dimerization of KIT extracellular domain mutants
output
[CandidateSet:R-HSA-9680199] extracellular domain mutant dimers of KIT [plasma membrane]
releaseDate
2020年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9678239] Serrano, C駸ar, 2020年03月13日
[InstanceEdit:9678232] Garc?a-Valverde, Alfonso, 2020年03月13日
[InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020年03月13日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9680242
summation
[Summation:9680241] Kit mutations in exon 8 and 9 affect the fifth Ig-like domai...
Referrals
(precedingEvent)
[Reaction:R-HSA-9680248] Phosphorylation of extracellular domain KIT mutants
(hasEvent)
[Pathway:R-HSA-9680187] Signaling by extracellular domain mutants of KIT
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