Reactome Pathway Database

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imatinib-sensitive PDGFR mutants [plasma membrane] Show undefined attributes

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:9672127] Rothfels, Karen, 2019年12月23日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 9672129

disease

[Disease:1500689] cancer

displayName imatinib-sensitive PDGFR mutants [plasma membrane]

hasMember

inDisease true

literatureReference

[LiteratureReference:9671319] A precision therapy against cancers driven by KIT/PDGFRA mutations
[LiteratureReference:9674274] Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants
[LiteratureReference:9671911] PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib
[LiteratureReference:9671429] Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors
[LiteratureReference:9673492] A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndrome
[LiteratureReference:9671886] Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

maxDepth 2

memberOf

[DefinedSet:R-HSA-9674351] type II TKI sensitive PDGFR mutants [plasma membrane] - Homo sapiens

modified [InstanceEdit:9674382] Rothfels, Karen, 2020年01月13日

name

imatinib-sensitive PDGFR mutants

schemaClass DefinedSet

species

[Species:48887] Homo sapiens

stId R-HSA-9672129

Referrals

(hasMember)

[DefinedSet:R-HSA-9674351] type II TKI sensitive PDGFR mutants [plasma membrane]

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