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Reaction
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Entries
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex
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authored
[InstanceEdit:9664643] Rothfels, Karen, 2019年10月25日
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9656210] Rothfels, Karen, 2019年07月27日
crossReference
[DatabaseIdentifier:11944929] Mondo:0009026
[DatabaseIdentifier:11944930] Mondo:0007893
[DatabaseIdentifier:11944933] Mondo:0005045
[DatabaseIdentifier:11944924] Mondo:0018997
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9656211
disease
[Disease:9651116] Costello syndrome
[Disease:9651118] LEOPARD syndrome
[Disease:6802289] Noonan syndrome
[Disease:1500689] cancer
[Disease:6788675] hypertrophic cardiomyopathy
displayName
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex
edited
[InstanceEdit:9690121] Rothfels, Karen, 2020年05月26日
entityFunctionalStatus
[EntityFunctionalStatus:9656204] gain_of_function of p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane]
eventOf
[Pathway:R-HSA-9656223] Signaling by RAF1 mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-9656215] RAF1 mutant complexes phosphorylate MAP2K dimer - Homo sapiens
input
[DefinedSet:R-HSA-5672716] MAP2K homo/heterodimers [cytosol]
[DefinedSet:R-HSA-169291] MAPKs [cytosol]
[Complex:R-HSA-9656176] p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane]
[CandidateSet:R-HSA-5672717] RAF/MAPK scaffolds [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:6790423] The RASopathies
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex
normalReaction
[Reaction:R-HSA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex
output
[Complex:R-HSA-9656179] activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane]
precedingEvent
[Reaction:R-HSA-9656212] Phosphorylation of RAF1 mutants - Homo sapiens
releaseDate
2020年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020年05月04日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9656211
summation
[Summation:9655944] MAP2K and MAPK proteins are likely recruited to complexes co...
Referrals
(precedingEvent)
[Reaction:R-HSA-9656215] RAF1 mutant complexes phosphorylate MAP2K dimer
(hasEvent)
[Pathway:R-HSA-9656223] Signaling by RAF1 mutants
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