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Schema
>
Reaction
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Entries
Activated BRAF recruits MAP2Ks and MAPKs to the endosome
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authored
[InstanceEdit:9610162] Rothfels, Karen, 2018年06月05日
category
binding
compartment
[Compartment:74700] endosome membrane
created
[InstanceEdit:9610162] Rothfels, Karen, 2018年06月05日
dbId
9610152
displayName
Activated BRAF recruits MAP2Ks and MAPKs to the endosome
eventOf
[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
followingEvent
[Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Homo sapiens
input
[DefinedSet:R-HSA-5672716] MAP2K homo/heterodimers [cytosol]
[DefinedSet:R-HSA-169291] MAPKs [cytosol]
[Complex:R-HSA-9610130] RAP1:GTP:activated BRAF dimer [endosome membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:182068] Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
[LiteratureReference:9610088] The neurotrophin receptor signaling endosome: Where trafficking meets signaling
[LiteratureReference:205022] Neurotrophin-regulated signalling pathways
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Activated BRAF recruits MAP2Ks and MAPKs to the endosome
negativePrecedingEvent
[NegativePrecedingEvent:9865769] Futile Cycle: Dissociation of phosphorylated MAP2Ks and MAPKs
orthologousEvent
[Reaction:R-CEL-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Caenorhabditis elegans
[Reaction:R-DME-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Drosophila melanogaster
[Reaction:R-GGA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Gallus gallus
[Reaction:R-SSC-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Sus scrofa
[Reaction:R-BTA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Bos taurus
[Reaction:R-RNO-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Rattus norvegicus
[Reaction:R-MMU-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Mus musculus
output
[Complex:R-HSA-9610134] RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane]
precedingEvent
[Reaction:R-HSA-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Homo sapiens
releaseDate
2019年09月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9658256] D'Eustachio, Peter, 2019年08月12日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9610152
summation
[Summation:9610161] Downstream of NGF stimulation and RAP1 activation, BRAF recr...
Referrals
(hasEvent)
[Pathway:R-HSA-170968] Frs2-mediated activation
(precedingEvent)
[Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
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