Reactome Pathway Database

Schema > Reaction > Entries

PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro Show undefined attributes

catalystActivity

[CatalystActivity:70663] pyrroline-5-carboxylate reductase activity of PYCR1 decamer [mitochondrial matrix]

catalystActivityReference [CatalystActivityReference:9643684] pyrroline-5-carboxylate reductase activity of PYCR1 decamer [mitochondrial matrix] Functional specialization in proline biosynthesis of melanoma

category transition

compartment

[Compartment:5460] mitochondrial matrix

crossReference

dbId 70664

displayName PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

eventOf

[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism - Homo sapiens

followingEvent

[Reaction:R-HSA-70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:11064438] Weiser, Joel, 2025年08月28日

name

PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
1-pyrroline-5-carboxylate + 2 H(+) + NADH => L-proline + NAD(+)

negativePrecedingEvent

[NegativePrecedingEvent:9930370] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)

orthologousEvent

output

precedingEvent

[Reaction:R-HSA-70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - Homo sapiens

previousReviewStatus [ReviewStatus:9821385] four stars

releaseDate 2004年07月06日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9927660] D'Eustachio, Peter, 2024年11月08日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-70664

summation

[Summation:178924] Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the re...

updateTrackers

Referrals

(updatedInstance)

(hasEvent)

[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism

(precedingEvent)

[Reaction:R-HSA-70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)

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