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Schema
>
Reaction
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Entries
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]
Show undefined attributes
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catalystActivity
[CatalystActivity:70605] glutamine synthetase activity of GLUL decamer [cytosol]
catalystActivityReference
[CatalystActivityReference:9643796] glutamate-ammonia ligase activity of GLUL decamer [cytosol] Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design
category
transition
compartment
[Compartment:70101] cytosol
crossReference
[DatabaseIdentifier:12610545] Rhea:16170
[DatabaseIdentifier:9925789] RHEA:16170
dbId
70606
deleted
[Deleted:660240] Deletion of instance: 210525
displayName
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]
eventOf
[Pathway:R-HSA-210455] Astrocytic Glutamate-Glutamine Uptake And Metabolism - Homo sapiens
[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism - Homo sapiens
followingEvent
[Reaction:R-HSA-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Homo sapiens
[Reaction:R-HSA-212614] Glutamine transport from astrocytes - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-29404] L-Glu [cytosol]
[SimpleEntity:R-ALL-31633] NH4+ [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:199781] Congenital glutamine deficiency with glutamine synthetase mutations
[LiteratureReference:507950] Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]
ATP + L-glutamate + NH4(+) => ADP + H(+) + L-glutamine + phosphate
orthologousEvent
[Reaction:R-SCE-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Saccharomyces cerevisiae
[Reaction:R-SPO-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Schizosaccharomyces pombe
[Reaction:R-CEL-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Caenorhabditis elegans
[Reaction:R-DME-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Drosophila melanogaster
[Reaction:R-GGA-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Gallus gallus
[Reaction:R-XTR-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Xenopus tropicalis
[Reaction:R-DRE-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Danio rerio
[Reaction:R-SSC-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Sus scrofa
[Reaction:R-BTA-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Bos taurus
[Reaction:R-CFA-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Canis familiaris
[Reaction:R-RNO-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Rattus norvegicus
[Reaction:R-MMU-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Mus musculus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29472] L-Gln [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent
[Reaction:R-HSA-210439] glutamate uptake by astrocytes - Homo sapiens
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2004年07月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9927660] D'Eustachio, Peter, 2024年11月08日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-70606
summation
[Summation:178810] Cytosolic glutamine synthetase (glutamate-ammonia ligase - G...
updateTrackers
[UpdateTracker:9791028] Update Tracker - [Reaction:70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - v32:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9928394] Update Tracker - [Reaction:70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - v91:[removeOutput]
[UpdateTracker:9792267] Update Tracker - [Reaction:70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - v22:[addLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9791028] Update Tracker - [Reaction:70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - v32:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9928394] Update Tracker - [Reaction:70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - v91:[removeOutput]
[UpdateTracker:9792267] Update Tracker - [Reaction:70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - v22:[addLiteratureReference]
(replacementInstances)
[Deleted:660240] Deletion of instance: 210525
(hasEvent)
[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism
[Pathway:R-HSA-210455] Astrocytic Glutamate-Glutamine Uptake And Metabolism
(precedingEvent)
[Reaction:R-HSA-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine
[Reaction:R-HSA-212614] Glutamine transport from astrocytes
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