Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
Show undefined attributes
Go to Details
authored
[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:6802931] Rothfels, Karen, 2015年10月02日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
6802934
disease
[Disease:1500689] cancer
displayName
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
edited
[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日
entityFunctionalStatus
[EntityFunctionalStatus:6802898] gain_of_function of p-BRAF/RAF fusion dimers [cytosol]
eventOf
[Pathway:R-HSA-6802952] Signaling by BRAF and RAF1 fusions - Homo sapiens
followingEvent
[Reaction:R-HSA-6802933] p-BRAF and RAF fusion dimers phosphorylate MAP2Ks - Homo sapiens
input
[DefinedSet:R-HSA-5672716] MAP2K homo/heterodimers [cytosol]
[DefinedSet:R-HSA-169291] MAPKs [cytosol]
[CandidateSet:R-HSA-6802698] p-BRAF/RAF fusion dimers [cytosol]
[CandidateSet:R-HSA-5672717] RAF/MAPK scaffolds [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:6800638] Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
[LiteratureReference:6800633] Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
[LiteratureReference:6800635] Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma
[LiteratureReference:6802072] Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer
[LiteratureReference:6800639] The landscape of kinase fusions in cancer
[LiteratureReference:6800632] BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition
[LiteratureReference:6802135] Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
[LiteratureReference:6800629] A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation
[LiteratureReference:6802031] Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers
[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
normalReaction
[Reaction:R-HSA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex
output
[Complex:R-HSA-6802695] p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol]
precedingEvent
[Reaction:R-HSA-6802927] BRAF and RAF fusion mutant dimers are phosphorylated - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-8936739] Negative regulation by 'p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane]'
releaseDate
2016年09月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-6802934
summation
[Summation:6802186] BRAF and RAF fusion proteins expressed in cancer constitutiv...
Referrals
(hasEvent)
[Pathway:R-HSA-6802952] Signaling by BRAF and RAF1 fusions
(precedingEvent)
[Reaction:R-HSA-6802933] p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル