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Schema > Reaction > Entries

High kinase activity BRAF mutants bind MAP2Ks and MAPKs Show undefined attributes

authored

[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日

category binding

compartment

[Compartment:70101] cytosol

created [InstanceEdit:6802913] Rothfels, Karen, 2015年10月02日

crossReference

dbId 6802912

disease

displayName High kinase activity BRAF mutants bind MAP2Ks and MAPKs

edited

[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日

entityFunctionalStatus

[EntityFunctionalStatus:6802883] gain_of_function of high kinase activity BRAF mutants [cytosol]

eventOf

[Pathway:R-HSA-6802948] Signaling by high-kinase activity BRAF mutants - Homo sapiens

followingEvent

[Reaction:R-HSA-6802911] High kinase activity BRAF complexes phosphorylate MAP2Ks - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

High kinase activity BRAF mutants bind MAP2Ks and MAPKs

normalReaction [Reaction:R-HSA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex

output

[Complex:R-HSA-6802662] high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol]

regulatedBy

[NegativeRegulation:R-HSA-8936741] Negative regulation by 'p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane]'

releaseDate 2016年09月19日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-6802912

summation

[Summation:6802198] High-kinase activity BRAF mutants such as the prevalent V600...

Referrals

(precedingEvent)

[Reaction:R-HSA-6802911] High kinase activity BRAF complexes phosphorylate MAP2Ks

(hasEvent)

[Pathway:R-HSA-6802948] Signaling by high-kinase activity BRAF mutants

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