Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
Translesion synthesis by POLK
Show undefined attributes
Go to Details
authored
[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014年12月11日
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5655863] Orlic-Milacic, Marija, 2014年12月09日
crossReference
[DatabaseIdentifier:12757938] BioModels Database:BIOMD0000000293
[DatabaseIdentifier:12757940] BioModels Database:BIOMD0000000220
dbId
5655862
deleted
[Deleted:5676176] Deletion of instance: 110325
displayName
Translesion synthesis by POLK
edited
[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014年12月11日
eventOf
[Pathway:R-HSA-110313] Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:10327] error-prone translesion synthesis
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Homo sapiens
[Reaction:R-HSA-5655892] POLK incorporates dNMP opposite to damaged DNA base - Homo sapiens
[Reaction:R-HSA-5655965] POLK and POLZ cooperate in elongation of mispaired primer termini - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5655844] Identification of a novel REV1-interacting motif necessary for DNA polymerase kappa function
[LiteratureReference:5655830] Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA
[LiteratureReference:5655901] Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides
[LiteratureReference:5655880] A role for DNA polymerase ? in promoting replication through oxidative DNA lesion, thymine glycol, in human cells
[LiteratureReference:5655893] Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases kappa and zeta in human cells
[LiteratureReference:5655883] Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro
[LiteratureReference:5655887] Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion
[LiteratureReference:5655894] Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa
[LiteratureReference:5655878] Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase ? elucidates error-free bypass of a bulky DNA lesion
[LiteratureReference:5655868] Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases
[LiteratureReference:5655973] Role of human DNA polymerase kappa as an extender in translesion synthesis
[LiteratureReference:5655978] Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Translesion synthesis by POLK
Translesion Synthesis by DNA Polymerase Kappa
orthologousEvent
[Pathway:R-PFA-5655862] Translesion synthesis by POLK - Plasmodium falciparum
[Pathway:R-SCE-5655862] Translesion synthesis by POLK - Saccharomyces cerevisiae
[Pathway:R-SPO-5655862] Translesion synthesis by POLK - Schizosaccharomyces pombe
[Pathway:R-DDI-5655862] Translesion synthesis by POLK - Dictyostelium discoideum
[Pathway:R-CEL-5655862] Translesion synthesis by POLK - Caenorhabditis elegans
[Pathway:R-DME-5655862] Translesion synthesis by POLK - Drosophila melanogaster
[Pathway:R-GGA-5655862] Translesion synthesis by POLK - Gallus gallus
[Pathway:R-XTR-5655862] Translesion synthesis by POLK - Xenopus tropicalis
[Pathway:R-SSC-5655862] Translesion synthesis by POLK - Sus scrofa
[Pathway:R-BTA-5655862] Translesion synthesis by POLK - Bos taurus
[Pathway:R-CFA-5655862] Translesion synthesis by POLK - Canis familiaris
[Pathway:R-RNO-5655862] Translesion synthesis by POLK - Rattus norvegicus
[Pathway:R-MMU-5655862] Translesion synthesis by POLK - Mus musculus
releaseDate
2015年03月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5663080] Borowiec, James, 2015年01月07日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5655862
summation
[Summation:5656198] DNA polymerase kappa (POLK) is a Y family DNA polymerase tha...
Referrals
(replacementInstances)
[Deleted:5676176] Deletion of instance: 110325
(hasEvent)
[Pathway:R-HSA-110313] Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル