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Schema
>
Complex
>
Entries
FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
Show undefined attributes
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catalystActivities
[CatalystActivity:5655274] guanyl-nucleotide exchange factor activity of FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日
crossReference
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
5655345
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
hasComponent
[Complex:R-HSA-5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane]
[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
inDisease
true
includedLocation
[Compartment:70101] cytosol
isChimeric
false
literatureReference
[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
maxDepth
7
name
FGFR2 mutants:p-FRS2:GRB2:SOS1
producedByEvent
[Reaction:R-HSA-5655233] Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens
schemaClass
Complex
species
[Species:48887] Homo sapiens
stId
R-HSA-5655345
updateTrackers
[UpdateTracker:9892450] Update Tracker - [Complex:5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9897917] Update Tracker - [Complex:5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9900920] Update Tracker - [Complex:5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v71:[updateContainedComponent]
[UpdateTracker:9893920] Update Tracker - [Complex:5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v56:[updateContainedComponent]
Referrals
(updatedInstance)
[UpdateTracker:9892450] Update Tracker - [Complex:5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9897917] Update Tracker - [Complex:5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9900920] Update Tracker - [Complex:5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v71:[updateContainedComponent]
[UpdateTracker:9893920] Update Tracker - [Complex:5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v56:[updateContainedComponent]
(diseaseEntity)
[EntityFunctionalStatus:5655292] gain_of_function of FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
(physicalEntity)
[CatalystActivity:5655274] guanyl-nucleotide exchange factor activity of FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
(output)
[Reaction:R-HSA-5655233] Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
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