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Schema
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Reaction
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Entries
Activated FGFR2 mutants phosphorylate FRS2
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authored
[InstanceEdit:2105031] Rothfels, K, 2012年02月09日
catalystActivity
[CatalystActivity:5655265] protein tyrosine kinase activity of Activated FGFR2 mutants:FRS2 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日
crossReference
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
5655268
deleted
[Deleted:5655667] Deletion of instance: 1982077
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
Activated FGFR2 mutants phosphorylate FRS2
edited
[InstanceEdit:2252592] Rothfels, K, 2012年05月16日
entityFunctionalStatus
[EntityFunctionalStatus:5655264] gain_of_function of Activated FGFR2 mutants:FRS2 [plasma membrane]
eventOf
[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease - Homo sapiens
followingEvent
[Reaction:R-HSA-5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
input
[Complex:R-HSA-5655257] Activated FGFR2 mutants:FRS2 [plasma membrane]
6 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
[LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer
[LiteratureReference:2033241] Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
[LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
[LiteratureReference:2067711] GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling
[LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling
[LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Activated FGFR2 mutants phosphorylate FRS2
normalReaction
[Reaction:R-HSA-5654397] Activated FGFR2 phosphorylates FRS2
output
[Complex:R-HSA-5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane]
6 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012年05月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5655268
summation
[Summation:1982078] After recruitment to activated FGFR mutants, FRS2 is believe...
Referrals
(replacementInstances)
[Deleted:5655667] Deletion of instance: 1982077
(precedingEvent)
[Reaction:R-HSA-5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
(hasEvent)
[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease
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