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Schema
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BlackBoxEvent
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Entries
Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes
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authored
[InstanceEdit:5228768] Rothfels, K, 2014年01月14日
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5229349] Rothfels, K, 2014年01月17日
dbId
5229348
displayName
Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes
edited
[InstanceEdit:5358774] Matthews, Lisa, 2014年04月03日
eventOf
[Pathway:R-HSA-4641265] Repression of WNT target genes - Homo sapiens
input
[CandidateSet:R-HSA-4411390] 'canonical' WNT target genes [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:3238089] The way Wnt works: Components and mechanism
[LiteratureReference:5229346] Context-dependent regulation of Groucho/TLE-mediated repression
[LiteratureReference:5334041] The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines
[LiteratureReference:5334038] TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription
[LiteratureReference:5334036] A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes
output
[CandidateSet:R-HSA-4411358] 'canonical' WNT target gene transcripts [nucleoplasm]
precedingEvent
[Reaction:R-HSA-4641231] TLE recruits HDAC1 to WNT promoters - Homo sapiens
[Reaction:R-HSA-5334050] TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes - Homo sapiens
regulatedBy
[NegativeGeneExpressionRegulation:R-HSA-5229351] Negative gene expression regulation by ''canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm]'
[NegativeGeneExpressionRegulation:R-HSA-5339676] Negative gene expression regulation by 'TCF7L2/TCF7L1:CTBPs [nucleoplasm]'
releaseDate
2014年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5251465] Rajakulendran, Nishani, 2014年01月22日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-5229348
summation
[Summation:5229347] Transcription of WNT genes is repressed in the absence of WN...
updateTrackers
[UpdateTracker:9786170] Update Tracker - [BlackBoxEvent:5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - v50:[add_removeRegulator]
[UpdateTracker:9782247] Update Tracker - [BlackBoxEvent:5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - v59:[add_removeRegulator]
Referrals
(updatedInstance)
[UpdateTracker:9786170] Update Tracker - [BlackBoxEvent:5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - v50:[add_removeRegulator]
[UpdateTracker:9782247] Update Tracker - [BlackBoxEvent:5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - v59:[add_removeRegulator]
(hasEvent)
[Pathway:R-HSA-4641265] Repression of WNT target genes
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