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Schema
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Entries
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants
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authored
[InstanceEdit:2958607] Orlic-Milacic, M, 2013年01月04日
catalystActivity
[CatalystActivity:1980072] ubiquitin-protein transferase activity of MIB/NEURL [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:2769005] Orlic-Milacic, M, 2012年12月10日
crossReference
[DatabaseIdentifier:11944984] Mondo:0004963
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
2769007
disease
[Disease:1485587] T-cell acute lymphoblastic leukemia
[Disease:1500689] cancer
displayName
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants
edited
[InstanceEdit:2980626] Jassal, B, 2013年01月09日
entityFunctionalStatus
[EntityFunctionalStatus:2775817] gain_of_function of DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane]
entityOnOtherCell
[CandidateSet:R-HSA-1911464] MIB/NEURL [cytosol] - Homo sapiens
[DefinedSet:R-HSA-157643] DLL/JAG [plasma membrane] - Homo sapiens
[DefinedSet:R-HSA-113595] Ub [cytosol] - Homo sapiens
eventOf
[Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants - Homo sapiens
input
[DefinedSet:R-HSA-2768995] DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane]
[DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1602210] An obligatory role of mind bomb-1 in notch signaling of mammalian development
[LiteratureReference:1602191] Mind bomb-2 is an E3 ligase for Notch ligand
[LiteratureReference:1602202] Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
[LiteratureReference:208262] The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
[LiteratureReference:208089] Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila
[LiteratureReference:208396] The interplay between DSL proteins and ubiquitin ligases in Notch signaling
[LiteratureReference:208133] Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta
[LiteratureReference:2084254] Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1
[LiteratureReference:2084252] Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants
normalReaction
[Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
output
[Complex:R-HSA-2769006] Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane]
releaseDate
2012年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:3110296] Haw, R, 2013年02月10日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2769007
summation
[Summation:2768991] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PES...
updateTrackers
[UpdateTracker:9784383] Update Tracker - [Reaction:2769007] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants - v54:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9784383] Update Tracker - [Reaction:2769007] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants - v54:[addLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants
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