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Entries
NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
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authored
[InstanceEdit:2958607] Orlic-Milacic, M, 2013年01月04日
catalystActivity
[CatalystActivity:1852619] metallopeptidase activity of ADAM10/17:Zn2+ [plasma membrane]
category
transition
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:2220965] Orlic-Milacic, M, 2012年05月03日
crossReference
[DatabaseIdentifier:11944984] Mondo:0004963
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
2220976
disease
[Disease:1500689] cancer
[Disease:1485587] T-cell acute lymphoblastic leukemia
displayName
NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
edited
[InstanceEdit:2980626] Jassal, B, 2013年01月09日
entityFunctionalStatus
[EntityFunctionalStatus:9630138] gain_of_function of NOTCH1 HD+PEST Domain Mutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
entityOnOtherCell
[DefinedSet:R-HSA-2902211] NOTCH1 HD+PEST Domain Mutant Fragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] - Homo sapiens
eventOf
[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-2220988] NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants - Homo sapiens
input
[DefinedSet:R-HSA-2902212] NOTCH1 HD+PEST Domain Mutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:2691227] Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
output
[DefinedSet:R-HSA-2289143] NEXT1 PEST domain mutants [plasma membrane]
[DefinedSet:R-HSA-2902211] NOTCH1 HD+PEST Domain Mutant Fragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane]
precedingEvent
[Reaction:R-HSA-2900765] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants - Homo sapiens
releaseDate
2012年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:3110296] Haw, R, 2013年02月10日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2220976
summation
[Summation:2902226] NOTCH1 HD domain mutants are cleaved at S2 and S3 sites to p...
Referrals
(hasEvent)
[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
(precedingEvent)
[Reaction:R-HSA-2220988] NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
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