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(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol
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authored
[InstanceEdit:1855226] Williams, MG, 2011年10月28日
catalystActivity
[CatalystActivity:2023955] inositol bisdiphosphate tetrakisphosphate diphosphatase activity of NUDT(1) [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:2023980] Williams, MG, 2011年12月13日
dbId
2023973
displayName
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol
edited
[InstanceEdit:1855226] Williams, MG, 2011年10月28日
eventOf
[Pathway:R-HSA-1855167] Synthesis of pyrophosphates in the cytosol - Homo sapiens
followingEvent
[Reaction:R-HSA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Homo sapiens
[Reaction:R-HSA-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Homo sapiens
[Reaction:R-HSA-1855194] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol - Homo sapiens
input
[DefinedSet:R-ALL-2023968] (PP)2-IP4 [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1889835] An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase
[LiteratureReference:1889813] The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein
[LiteratureReference:1889932] A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase
[LiteratureReference:1889831] Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates
[LiteratureReference:1889818] Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family
[LiteratureReference:1889819] Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol
orthologousEvent
[Reaction:R-DDI-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Dictyostelium discoideum
[Reaction:R-DRE-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Danio rerio
[Reaction:R-CEL-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Caenorhabditis elegans
[Reaction:R-MMU-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Mus musculus
[Reaction:R-RNO-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Rattus norvegicus
[Reaction:R-CFA-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Canis familiaris
[Reaction:R-BTA-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Bos taurus
[Reaction:R-SCE-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Saccharomyces cerevisiae
[Reaction:R-SPO-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Schizosaccharomyces pombe
[Reaction:R-DME-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Drosophila melanogaster
[Reaction:R-GGA-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Gallus gallus
[Reaction:R-XTR-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Xenopus tropicalis
[Reaction:R-SSC-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Sus scrofa
output
[DefinedSet:R-ALL-2023974] 1/3-PP-IP5 [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent
[Reaction:R-HSA-1855220] (PP)2-IP4 transports from the nucleus to the cytosol - Homo sapiens
[Reaction:R-HSA-1855194] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol - Homo sapiens
[Reaction:R-HSA-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Homo sapiens
releaseDate
2012年12月04日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2562610] Wundenberg, Torsten, 2012年11月06日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2023973
summation
[Summation:2023963] Diphosphoinositol polyphosphate phosphohydrolases (DIPP), al...
Referrals
(hasEvent)
[Pathway:R-HSA-1855167] Synthesis of pyrophosphates in the cytosol
(precedingEvent)
[Reaction:R-HSA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
[Reaction:R-HSA-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus
[Reaction:R-HSA-1855194] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol
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