Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
Assembly of the destruction complex
Show undefined attributes
Go to Details
authored
[InstanceEdit:195289] Kimelman, D, 2007年04月03日 12:34:14
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:195252] Matthews, L, 2007年04月03日 04:36:56
dbId
195251
displayName
Assembly of the destruction complex
edited
[InstanceEdit:195272] Matthews, L, 2007年04月03日 12:38:03
eventOf
[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex - Homo sapiens
followingEvent
[Reaction:R-HSA-5229343] AXIN is phosphorylated in the destruction complex - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:8854798] beta-catenin destruction complex assembly
input
[EntityWithAccessionedSequence:R-HSA-1504189] AMER1 [cytosol]
[EntityWithAccessionedSequence:R-HSA-195249] AXIN1 [cytosol]
[EntityWithAccessionedSequence:R-HSA-195263] CSNK1A1 [cytosol]
[EntityWithAccessionedSequence:R-HSA-2997551] GSK3B [cytosol]
[EntityWithAccessionedSequence:R-HSA-5246690] K63polyUb-APC [cytosol]
[Complex:R-HSA-196206] PP2A [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:196219] Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex
[LiteratureReference:196218] Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
[LiteratureReference:2130275] Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
maxDepth
1
modified
[InstanceEdit:10424722] Weiser, Joel, 2025年08月27日
name
Assembly of the destruction complex
orthologousEvent
[Reaction:R-SSC-195251] Assembly of the destruction complex - Sus scrofa
[Reaction:R-BTA-195251] Assembly of the destruction complex - Bos taurus
[Reaction:R-CFA-195251] Assembly of the destruction complex - Canis familiaris
[Reaction:R-RNO-195251] Assembly of the destruction complex - Rattus norvegicus
[Reaction:R-MMU-195251] Assembly of the destruction complex - Mus musculus
output
[Complex:R-HSA-195250] AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
precedingEvent
[Reaction:R-HSA-5246693] APC is K63-polyubiquitinated - Homo sapiens
[BlackBoxEvent:R-HSA-5251557] Expression of AMER1 gene - Homo sapiens
[BlackBoxEvent:R-HSA-5251555] Expression of AXIN1 gene - Homo sapiens
releaseDate
2007年05月15日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:196987] Pagano, M, 2007年04月27日 13:02:18
revised
[InstanceEdit:5433076] Salahshor, S, 2014年05月12日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-195251
summation
[Summation:196244] The exact composition of the destruction complex is not know...
updateTrackers
[UpdateTracker:9788860] Update Tracker - [Reaction:195251] Assembly of the destruction complex - v40:[addInput, addLiteratureReference]
[UpdateTracker:9786464] Update Tracker - [Reaction:195251] Assembly of the destruction complex - v49:[add_removeInput]
[UpdateTracker:9787789] Update Tracker - [Reaction:195251] Assembly of the destruction complex - v44:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9788860] Update Tracker - [Reaction:195251] Assembly of the destruction complex - v40:[addInput, addLiteratureReference]
[UpdateTracker:9786464] Update Tracker - [Reaction:195251] Assembly of the destruction complex - v49:[add_removeInput]
[UpdateTracker:9787789] Update Tracker - [Reaction:195251] Assembly of the destruction complex - v44:[add_removeInput]
(normalReaction)
[FailedReaction:R-HSA-4839734] AXIN mutants destabilize the destruction complex
[FailedReaction:R-HSA-4839746] Truncated AMER1 mutants destabilize the destruction complex
[FailedReaction:R-HSA-4791278] APC truncation mutants have impaired AXIN binding
(hasEvent)
[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex
(precedingEvent)
[Reaction:R-HSA-5229343] AXIN is phosphorylated in the destruction complex
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル