Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
EntityWithAccessionedSequence
>
Entries
FGFR3 K650E [plasma membrane]
Show undefined attributes
Go to Details
compartment
[Compartment:876] plasma membrane
componentOf
[Complex:R-HSA-2033332] FGFR3 K650E mutant dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-2033332] FGFR3 K650E mutant dimer [plasma membrane] - Homo sapiens
created
[InstanceEdit:1614399] Rothfels, K, 2011年09月28日
crossReference
[DatabaseIdentifier:11945428] Mondo:0017042
[DatabaseIdentifier:11945426] Mondo:0005447
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944942] Mondo:0009693
[DatabaseIdentifier:11945164] Mondo:0004986
[DatabaseIdentifier:11944892] Mondo:0004992
[DatabaseIdentifier:2032954] COSMIC:COSV53390625
[DatabaseIdentifier:2032953] COSMIC:COSM35899
dbId
1614400
disease
[Disease:2032940] bone development disease
[Disease:1625209] thanatophoric dysplasia
[Disease:1500689] cancer
[Disease:1493885] bladder carcinoma
[Disease:1614388] multiple myeloma
[Disease:2032943] testicular cancer
displayName
FGFR3 K650E [plasma membrane]
endCoordinate
806
hasModifiedResidue
[ReplacedResidue:1614401] L-lysine 650 replaced with L-glutamic acid
inDisease
true
literatureReference
[LiteratureReference:2018771] Patterns of somatic mutation in human cancer genomes
[LiteratureReference:1226112] Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas
[LiteratureReference:2032927] Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype
[LiteratureReference:2032919] Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors
[LiteratureReference:2032925] Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations
[LiteratureReference:2032939] The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells
[LiteratureReference:1637849] Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
[LiteratureReference:2032916] A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene
maxDepth
1
memberOf
[CandidateSet:R-HSA-2018770] FGFR3 point mutants with enhanced kinase activity [plasma membrane] - Homo sapiens
[CandidateSet:R-HSA-2038374] FGFR3 (4;14) translocation mutants [plasma membrane] - Homo sapiens
modified
[InstanceEdit:5649563] Rothfels, Karen, 2014年11月20日
name
FGFR3 K650E
referenceEntity
[ReferenceGeneProduct:uniprot:P22607] UniProt:P22607 FGFR3
referenceType
ReferenceGeneProduct
schemaClass
EntityWithAccessionedSequence
species
[Species:48887] Homo sapiens
stId
R-HSA-1614400
startCoordinate
23
updateTrackers
[UpdateTracker:9890883] Update Tracker - [EntityWithAccessionedSequence:1614400] FGFR3 K650E [plasma membrane] - v52:[modifyName]
Referrals
(updatedInstance)
[UpdateTracker:9890883] Update Tracker - [EntityWithAccessionedSequence:1614400] FGFR3 K650E [plasma membrane] - v52:[modifyName]
(hasMember)
[CandidateSet:R-HSA-2018770] FGFR3 point mutants with enhanced kinase activity [plasma membrane]
[CandidateSet:R-HSA-2038374] FGFR3 (4;14) translocation mutants [plasma membrane]
(hasComponent)
[Complex:R-HSA-2033332] FGFR3 K650E mutant dimer [plasma membrane]
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル