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Schema
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Reaction
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Entries
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine
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catalystActivity
[CatalystActivity:74238] purine-nucleoside phosphorylase activity of PNP trimer [cytosol]
catalystActivityReference
[CatalystActivityReference:9643298] purine-nucleoside phosphorylase activity of NP trimer [cytosol] Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:112010] D'Eustachio, P, 2004年03月31日 17:07:00
crossReference
[DatabaseIdentifier:12610704] Rhea:27648
dbId
112033
deleted
[Deleted:500254] Deletion of instance: 112031
[Deleted:500251] Deletion of instance: 112017
displayName
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine
eventOf
[Pathway:R-HSA-74217] Purine salvage - Homo sapiens
input
[SimpleEntity:R-ALL-113599] Hyp [cytosol]
[DefinedSet:R-ALL-500244] R1P, dRibP [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:112023] Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides
[LiteratureReference:112027] A human purine nucleoside phosphorylase deficiency caused by a single base change
[LiteratureReference:112018] Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine
hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)
orthologousEvent
[Reaction:R-SCE-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - Saccharomyces cerevisiae
[Reaction:R-SPO-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - Schizosaccharomyces pombe
[Reaction:R-CEL-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - Caenorhabditis elegans
[Reaction:R-DME-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - Drosophila melanogaster
[Reaction:R-XTR-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - Xenopus tropicalis
[Reaction:R-DRE-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - Danio rerio
[Reaction:R-SSC-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - Sus scrofa
[Reaction:R-BTA-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - Bos taurus
[Reaction:R-CFA-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - Canis familiaris
[Reaction:R-RNO-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - Rattus norvegicus
[Reaction:R-MMU-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - Mus musculus
output
[DefinedSet:R-ALL-500172] Ino, dI [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate
2004年07月06日
reverseReaction
[Reaction:R-HSA-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose
reviewStatus
[ReviewStatus:9821382] five stars
revised
[InstanceEdit:504064] D'Eustachio, P, 2010年02月05日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-112033
summation
[Summation:178878] Cytosolic purine nucleoside phosphorylase (PNP) trimer catal...
updateTrackers
[UpdateTracker:9775648] Update Tracker - [Reaction:112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - v78:[modifyText]
[UpdateTracker:9791173] Update Tracker - [Reaction:112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9775353] Update Tracker - [Reaction:112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - v79:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9775648] Update Tracker - [Reaction:112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - v78:[modifyText]
[UpdateTracker:9791173] Update Tracker - [Reaction:112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9775353] Update Tracker - [Reaction:112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine - v79:[modifyText]
(replacementInstances)
[Deleted:500254] Deletion of instance: 112031
[Deleted:500251] Deletion of instance: 112017
(hasEvent)
[Pathway:R-HSA-74217] Purine salvage
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