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Schema
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Release
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Entries
53 on 2015年07月02日
Show undefined attributes
dbId
9784545
displayName
53 on 2015年07月02日
releaseDate
2015年07月02日
releaseNumber
53
schemaClass
Release
Referrals
(release)
[UpdateTracker:9784604] Update Tracker - [Pathway:5663202] Diseases of signal transduction by growth factor receptors and second messengers - v53:[updateContainedPathway]
[UpdateTracker:9784837] Update Tracker - [Reaction:917888] apoTF binds 2Fe3+ to form holoTF - v53:[modifyText]
[UpdateTracker:9784744] Update Tracker - [Pathway:881907] Gastrin-CREB signalling pathway via PKC and MAPK - v53:[add_removeHasEvent]
[UpdateTracker:9784733] Update Tracker - [Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - v53:[updateContainedRLE]
[UpdateTracker:9784841] Update Tracker - [Reaction:429698] PRKD1,2,3 phosphorylates CERT1-2 - v53:[modifyText]
[UpdateTracker:9784560] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v53:[updateContainedPathway]
[UpdateTracker:9784662] Update Tracker - [Pathway:1226099] Signaling by FGFR in disease - v53:[add_removeLiteratureReference, add_removeSummation, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784777] Update Tracker - [Pathway:422356] Regulation of insulin secretion - v53:[updateContainedRLE]
[UpdateTracker:9784780] Update Tracker - [Pathway:1236394] Signaling by ERBB4 - v53:[updateContainedPathway]
[UpdateTracker:9784857] Update Tracker - [Pathway:449147] Signaling by Interleukins - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784722] Update Tracker - [Pathway:1963640] GRB2 events in ERBB2 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784683] Update Tracker - [Reaction:169260] Reducing equivalents from beta-oxidation of fatty acids transfer to ETF - v53:[modifyText]
[UpdateTracker:9784617] Update Tracker - [Reaction:75096] Docking of the TAP:EJC Complex with the NPC - v53:[removeOutput]
[UpdateTracker:9784787] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v53:[updateIndirectRLE]
[UpdateTracker:9784856] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v53:[updateIndirectRLE]
[UpdateTracker:9784824] Update Tracker - [Pathway:196071] Metabolism of steroid hormones - v53:[updateIndirectRLE]
[UpdateTracker:9784725] Update Tracker - [Pathway:165159] MTOR signalling - v53:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784713] Update Tracker - [Reaction:433599] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v53:[modifyText]
[UpdateTracker:9784807] Update Tracker - [Pathway:193704] p75 NTR receptor-mediated signalling - v53:[updateIndirectRLE]
[UpdateTracker:9784633] Update Tracker - [Reaction:83660] Membrane-anchored TNF-alpha binds TNFR1 - v53:[modifyText]
[UpdateTracker:9784594] Update Tracker - [Pathway:167160] RNA Pol II CTD phosphorylation and interaction with CE during HIV infection - v53:[updateContainedRLE]
[UpdateTracker:9784648] Update Tracker - [Reaction:109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS - v53:[modifyText]
[UpdateTracker:9784663] Update Tracker - [Pathway:176974] Unwinding of DNA - v53:[updateContainedRLE]
[UpdateTracker:9784576] Update Tracker - [Pathway:427652] Sodium-coupled phosphate cotransporters - v53:[updateIndirectRLE]
[UpdateTracker:9784847] Update Tracker - [Pathway:168188] Toll Like Receptor TLR6:TLR2 Cascade - v53:[updateContainedPathway]
[UpdateTracker:9784811] Update Tracker - [Reaction:167117] Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition - v53:[modifyText]
[UpdateTracker:9784638] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v53:[addRegulator, modifyText]
[UpdateTracker:9784568] Update Tracker - [Reaction:167136] Addition of nucleotides 5 through 9 on the growing HIV-1 transcript - v53:[modifyText]
[UpdateTracker:9784750] Update Tracker - [Pathway:1643685] Disease - v53:[addHasEvent, updateContainedPathway]
[UpdateTracker:9784636] Update Tracker - [Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - v53:[updateContainedPathway]
[UpdateTracker:9784627] Update Tracker - [Pathway:2262752] Cellular responses to stress - v53:[addHasEvent, updateContainedPathway]
[UpdateTracker:9784578] Update Tracker - [Reaction:1839100] p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions - v53:[add_removeOutput]
[UpdateTracker:9784623] Update Tracker - [Pathway:2559586] DNA Damage/Telomere Stress Induced Senescence - v53:[addHasEvent, updateContainedRLE]
[UpdateTracker:9784675] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v53:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784632] Update Tracker - [Pathway:162699] Synthesis of dolichyl-phosphate mannose - v53:[updateContainedRLE]
[UpdateTracker:9784767] Update Tracker - [Reaction:165680] Formation of active mTORC1 complex - v53:[add_removeInput, modifyText]
[UpdateTracker:9784710] Update Tracker - [Reaction:200421] Activation of cytosolic AMPK by phosphorylation - v53:[modifyText]
[UpdateTracker:9784691] Update Tracker - [Pathway:112399] IRS-mediated signalling - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784784] Update Tracker - [Pathway:167044] Signalling to RAS - v53:[add_removeHasEvent]
[UpdateTracker:9784804] Update Tracker - [Reaction:1839098] Activated FGFR1 mutants and fusions phosphorylate PLCG1 - v53:[add_removeLiteratureReference, add_removeSummation]
[UpdateTracker:9784615] Update Tracker - [Pathway:72172] mRNA Splicing - v53:[updateIndirectRLE]
[UpdateTracker:9784580] Update Tracker - [Pathway:5668914] Diseases of metabolism - v53:[updateContainedPathway]
[UpdateTracker:9784776] Update Tracker - [Reaction:446201] PMM1,2 isomerise Man6P to Man1P - v53:[modifyText]
[UpdateTracker:9784610] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784669] Update Tracker - [Reaction:193653] NGF homodimer binds to p75NTR - v53:[modifyText]
[UpdateTracker:9784562] Update Tracker - [Reaction:4084999] NEU1 hydrolyses Neu5Ac from glycoconjugates - v53:[modifyText]
[UpdateTracker:9784595] Update Tracker - [Pathway:1250347] SHC1 events in ERBB4 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784628] Update Tracker - [BlackBoxEvent:75850] Addition of the third nucleotide on the nascent transcript - v53:[modifyText]
[UpdateTracker:9784816] Update Tracker - [Pathway:1280215] Cytokine Signaling in Immune system - v53:[addHasEvent, updateContainedPathway]
[UpdateTracker:9784557] Update Tracker - [Reaction:109857] MAP2K1 binds MAPK3 - v53:[modifyText]
[UpdateTracker:9784741] Update Tracker - [Reaction:428185] sphinganine + stearyl-CoA => dihydroceramide + CoASH - v53:[modifyText]
[UpdateTracker:9784814] Update Tracker - [Pathway:187706] Signalling to p38 via RIT and RIN - v53:[add_removeHasEvent]
[UpdateTracker:9784642] Update Tracker - [Reaction:372705] Recruitment of BCAR1 to PTK2 complex - v53:[addLiteratureReference]
[UpdateTracker:9784708] Update Tracker - [Reaction:449715] GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P - v53:[modifyText]
[UpdateTracker:9784552] Update Tracker - [Reaction:75172] Formation of RAD50:MRE11 complex - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784681] Update Tracker - [Reaction:451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex - v53:[addRegulator, modifyText]
[UpdateTracker:9784702] Update Tracker - [Pathway:177929] Signaling by EGFR - v53:[updateContainedPathway]
[UpdateTracker:9784778] Update Tracker - [Reaction:112378] SOS mediated nucleotide exchange of RAS (SHC) - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784613] Update Tracker - [Pathway:211859] Biological oxidations - v53:[modifyText]
[UpdateTracker:9784802] Update Tracker - [Pathway:3700989] Transcriptional Regulation by TP53 - v53:[updateIndirectRLE]
[UpdateTracker:9784724] Update Tracker - [Pathway:5654743] Signaling by FGFR4 - v53:[updateContainedPathway]
[UpdateTracker:9784842] Update Tracker - [Pathway:167172] Transcription of the HIV genome - v53:[updateIndirectRLE]
[UpdateTracker:9784791] Update Tracker - [Reaction:3785768] MRN complex binds DNA double strand breaks - v53:[add_removeInput, modifyText, removeLiteratureReference]
[UpdateTracker:9784788] Update Tracker - [Pathway:422475] Axon guidance - v53:[updateContainedPathway]
[UpdateTracker:9784706] Update Tracker - [Reaction:532549] MPI isomerises Fru6P to Man6P - v53:[modifyText]
[UpdateTracker:9784745] Update Tracker - [Reaction:165766] Phosphorylation and activation of eIF4G by activated S6K1 - v53:[modifyText]
[UpdateTracker:9784752] Update Tracker - [Pathway:375165] NCAM signaling for neurite out-growth - v53:[add_removeHasEvent]
[UpdateTracker:9784800] Update Tracker - [Pathway:163685] Integration of energy metabolism - v53:[updateIndirectRLE]
[UpdateTracker:9784597] Update Tracker - [Pathway:983705] Signaling by the B Cell Receptor (BCR) - v53:[updateIndirectRLE]
[UpdateTracker:9784567] Update Tracker - [Pathway:5655253] Signaling by FGFR2 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway]
[UpdateTracker:9784635] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v53:[updateContainedRLE]
[UpdateTracker:9784797] Update Tracker - [Reaction:109860] MAP2K1 phosphorylates MAPK3 - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784809] Update Tracker - [Pathway:109703] PKB-mediated events - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784640] Update Tracker - [Pathway:451927] Interleukin-2 family signaling - v53:[add_removeHasEvent, updateContainedPathway]
[UpdateTracker:9784721] Update Tracker - [Pathway:2559583] Cellular Senescence - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784608] Update Tracker - [Pathway:3928662] EPHB-mediated forward signaling - v53:[updateContainedRLE]
[UpdateTracker:9784690] Update Tracker - [Reaction:162721] dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose - v53:[modifyText]
[UpdateTracker:9784768] Update Tracker - [Reaction:429714] monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP - v53:[modifyText]
[UpdateTracker:9784544] Update Tracker - [Reaction:165718] mTORC1 phosphorylation of RPS6KB1 (S6K) - v53:[add_removeRegulator]
[UpdateTracker:9784835] Update Tracker - [Reaction:165182] Phosphorylation of complexed TSC2 by PKB - v53:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9784660] Update Tracker - [Pathway:167162] RNA Polymerase II HIV Promoter Escape - v53:[updateContainedRLE]
[UpdateTracker:9784717] Update Tracker - [Pathway:72086] mRNA Capping - v53:[updateContainedRLE]
[UpdateTracker:9784714] Update Tracker - [Reaction:76576] Addition of nucleotides 10 and 11 on the growing transcript: Third Transition - v53:[modifyText]
[UpdateTracker:9784598] Update Tracker - [Pathway:3247509] Chromatin modifying enzymes - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784659] Update Tracker - [Pathway:2172127] DAP12 interactions - v53:[updateContainedPathway]
[UpdateTracker:9784709] Update Tracker - [Pathway:165158] Activation of AKT2 - v53:[updateContainedRLE]
[UpdateTracker:9784676] Update Tracker - [BlackBoxEvent:109863] Dissociation of p-T,Y-MAPK3:MAP2K1 - v53:[modifyText]
[UpdateTracker:9784854] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v53:[updateContainedRLE]
[UpdateTracker:9784839] Update Tracker - [Pathway:5653656] Vesicle-mediated transport - v53:[addLiteratureReference, addSummation]
[UpdateTracker:9784589] Update Tracker - [Reaction:427656] SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol - v53:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9784664] Update Tracker - [Reaction:109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 - v53:[add_removeOutput, removeInput]
[UpdateTracker:9784596] Update Tracker - [BlackBoxEvent:167121] Addition of the third nucleotide on the nascent HIV-1 transcript - v53:[modifyText]
[UpdateTracker:9784591] Update Tracker - [Reaction:114689] PLC gamma 2-mediated PIP2 hydrolysis - v53:[addRegulator]
[UpdateTracker:9784849] Update Tracker - [Reaction:75873] Addition of Nucleotides 5 through 9 on the growing Transcript - v53:[modifyText]
[UpdateTracker:9784795] Update Tracker - [Pathway:211000] Gene Silencing by RNA - v53:[updateIndirectRLE]
[UpdateTracker:9784693] Update Tracker - [Pathway:77075] RNA Pol II CTD phosphorylation and interaction with CE - v53:[updateContainedRLE]
[UpdateTracker:9784840] Update Tracker - [Reaction:4093339] p120-RasGAP activates GTP hydrolysis on RAS, inactivating it - v53:[add_removeInput, add_removeOutput]
[UpdateTracker:9784650] Update Tracker - [Reaction:74737] p-Y-IRS1,p-Y-IRS2 bind PI3K - v53:[add_removeInput]
[UpdateTracker:9784592] Update Tracker - [Pathway:446205] Synthesis of GDP-mannose - v53:[updateContainedRLE]
[UpdateTracker:9784687] Update Tracker - [Reaction:3371353] Soluble TNF-alpha binds TNFR1 - v53:[modifyText]
[UpdateTracker:9784796] Update Tracker - [Pathway:69473] G2/M DNA damage checkpoint - v53:[updateContainedRLE]
[UpdateTracker:9784757] Update Tracker - [Reaction:75174] Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784846] Update Tracker - [Pathway:73857] RNA Polymerase II Transcription - v53:[updateIndirectRLE]
[UpdateTracker:9784672] Update Tracker - [Reaction:194023] HSD11B2,HSD11B1 dimer oxidise CORT to COR - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784828] Update Tracker - [Pathway:354192] Integrin signaling - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784600] Update Tracker - [Reaction:165162] Phosphorylation of TSC2 by PKB - v53:[modifyText]
[UpdateTracker:9784806] Update Tracker - [Pathway:186763] Downstream signal transduction - v53:[add_removeHasEvent]
[UpdateTracker:9784614] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v53:[updateContainedRLE]
[UpdateTracker:9784551] Update Tracker - [Reaction:74716] Insulin binds the insulin receptor - v53:[modifyText]
[UpdateTracker:9784762] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v53:[addHasEvent]
[UpdateTracker:9784859] Update Tracker - [Reaction:169270] ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 - v53:[modifyText]
[UpdateTracker:9784625] Update Tracker - [Pathway:373760] L1CAM interactions - v53:[updateIndirectRLE]
[UpdateTracker:9784705] Update Tracker - [Reaction:264758] BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 - v53:[modifyText]
[UpdateTracker:9784620] Update Tracker - [Reaction:5578744] Importin-8 imports AGO2:miRNA into the nucleus - v53:[add_removeCatalystActivity]
[UpdateTracker:9784775] Update Tracker - [Pathway:190241] FGFR2 ligand binding and activation - v53:[updateContainedPathway]
[UpdateTracker:9784726] Update Tracker - [Reaction:164509] Binding of gp120 of ENV oligomer to the host CD4 - v53:[modifyText]
[UpdateTracker:9784549] Update Tracker - [Pathway:3229121] Glycogen storage diseases - v53:[removeHasEvent]
[UpdateTracker:9784790] Update Tracker - [Reaction:5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784621] Update Tracker - [Reaction:2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - v53:[add_removeInput, modifyText]
[UpdateTracker:9784764] Update Tracker - [Reaction:74712] Dissociation of IRS-P from insulin receptor - v53:[add_removeOutput]
[UpdateTracker:9784815] Update Tracker - [Reaction:109955] Formation of ERCC1:XPF heterodimeric complex - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784716] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v53:[updateContainedPathway]
[UpdateTracker:9784754] Update Tracker - [Pathway:71291] Metabolism of amino acids and derivatives - v53:[updateIndirectRLE]
[UpdateTracker:9784577] Update Tracker - [Pathway:446199] Synthesis of Dolichyl-phosphate - v53:[updateContainedRLE]
[UpdateTracker:9784831] Update Tracker - [Pathway:427589] Type II Na+/Pi cotransporters - v53:[updateContainedRLE]
[UpdateTracker:9784653] Update Tracker - [Reaction:4085021] GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP - v53:[modifyText]
[UpdateTracker:9784805] Update Tracker - [Reaction:265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - v53:[modifyText]
[UpdateTracker:9784634] Update Tracker - [Pathway:168142] Toll Like Receptor 10 (TLR10) Cascade - v53:[updateContainedPathway]
[UpdateTracker:9784569] Update Tracker - [Pathway:1369062] ABC transporters in lipid homeostasis - v53:[addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9784661] Update Tracker - [Pathway:162582] Signal Transduction - v53:[add_removeHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784609] Update Tracker - [Reaction:75998] Formation of RAD52 heptameric ring structure complexes - v53:[add_removeLiteratureReference, add_removeOutput, modifyText, removeInput]
[UpdateTracker:9784655] Update Tracker - [Pathway:5654708] Downstream signaling of activated FGFR3 - v53:[updateContainedPathway]
[UpdateTracker:9784644] Update Tracker - [Pathway:5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) - v53:[updateContainedRLE]
[UpdateTracker:9784601] Update Tracker - [Reaction:453200] SYK autophosphorylates - v53:[addRegulator, modifyText]
[UpdateTracker:9784674] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v53:[updateIndirectRLE]
[UpdateTracker:9784586] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v53:[add_removeHasEvent]
[UpdateTracker:9784583] Update Tracker - [Reaction:983707] SYK autophosphorylates at the activated BCR - v53:[addRegulator]
[UpdateTracker:9784848] Update Tracker - [Reaction:140978] TRADD:TRAF2:RIP1 complex binds FADD - v53:[modifyText]
[UpdateTracker:9784812] Update Tracker - [Reaction:165708] Dissociation of phosphorylated 4EBP1 from eIF4E - v53:[modifyText]
[UpdateTracker:9784798] Update Tracker - [Pathway:163210] Formation of ATP by chemiosmotic coupling - v53:[updateContainedRLE]
[UpdateTracker:9784858] Update Tracker - [Pathway:72202] Transport of Mature Transcript to Cytoplasm - v53:[updateIndirectRLE]
[UpdateTracker:9784641] Update Tracker - [Reaction:1369052] ABCAs mediate lipid influx - v53:[addInput, addOutput, modifyText, removeLiteratureReference]
[UpdateTracker:9784783] Update Tracker - [Pathway:112412] SOS-mediated signalling - v53:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9784838] Update Tracker - [Pathway:180336] SHC1 events in EGFR signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784855] Update Tracker - [Pathway:74751] Insulin receptor signalling cascade - v53:[add_removeHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784850] Update Tracker - [Pathway:112411] MAPK1 (ERK2) activation - v53:[addLiteratureReference, modifyText, removeHasEvent, updateContainedRLE]
[UpdateTracker:9784774] Update Tracker - [Pathway:1266738] Developmental Biology - v53:[addHasEvent, updateContainedPathway]
[UpdateTracker:9784667] Update Tracker - [Pathway:109704] PI3K Cascade - v53:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784553] Update Tracker - [Reaction:109702] PDPK1 phosphorylates AKT2 - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784548] Update Tracker - [Pathway:168256] Immune System - v53:[updateContainedPathway]
[UpdateTracker:9784556] Update Tracker - [Pathway:3214841] PKMTs methylate histone lysines - v53:[updateContainedRLE]
[UpdateTracker:9784830] Update Tracker - [Pathway:5654716] Downstream signaling of activated FGFR4 - v53:[updateContainedPathway]
[UpdateTracker:9784739] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v53:[updateContainedPathway]
[UpdateTracker:9784565] Update Tracker - [Reaction:109858] MAP2K2 binds MAPK1 - v53:[modifyText]
[UpdateTracker:9784829] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v53:[modifyText]
[UpdateTracker:9784585] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v53:[modifyText]
[UpdateTracker:9784712] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v53:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9784729] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v53:[updateContainedPathway]
[UpdateTracker:9784786] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784789] Update Tracker - [Reaction:446195] DOLK phosphorylates DCHOL to DOLP - v53:[modifyText]
[UpdateTracker:9784566] Update Tracker - [Pathway:4839726] Chromatin organization - v53:[updateContainedPathway]
[UpdateTracker:9784758] Update Tracker - [Pathway:162594] Early Phase of HIV Life Cycle - v53:[updateIndirectRLE]
[UpdateTracker:9784698] Update Tracker - [Pathway:446219] Synthesis of substrates in N-glycan biosythesis - v53:[updateIndirectRLE]
[UpdateTracker:9784770] Update Tracker - [Pathway:165181] Inhibition of TSC complex formation by PKB - v53:[modifyText, updateContainedRLE]
[UpdateTracker:9784719] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v53:[add_removeHasEvent]
[UpdateTracker:9784810] Update Tracker - [Pathway:3781865] Diseases of glycosylation - v53:[addHasEvent]
[UpdateTracker:9784827] Update Tracker - [Pathway:1839126] FGFR2 mutant receptor activation - v53:[add_removeLiteratureReference, add_removeSummation, updateIndirectRLE]
[UpdateTracker:9784678] Update Tracker - [Reaction:380979] RHEB in mTORC1:RHEB:GTP hydrolyses GTP - v53:[add_removeOutput, modifyText]
[UpdateTracker:9784656] Update Tracker - [Reaction:83582] TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. - v53:[modifyText]
[UpdateTracker:9784730] Update Tracker - [Pathway:74160] Gene expression (Transcription) - v53:[updateIndirectRLE]
[UpdateTracker:9784590] Update Tracker - [Pathway:1280218] Adaptive Immune System - v53:[updateContainedPathway]
[UpdateTracker:9784737] Update Tracker - [Pathway:5654738] Signaling by FGFR2 - v53:[updateContainedPathway]
[UpdateTracker:9784593] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v53:[add_removeSummation, removeLiteratureReference, updateContainedPathway]
[UpdateTracker:9784852] Update Tracker - [Pathway:611105] Respiratory electron transport - v53:[updateContainedRLE]
[UpdateTracker:9784817] Update Tracker - [Reaction:4085028] GNE phosphorylates ManNAc to ManNAc-6-P - v53:[modifyText]
[UpdateTracker:9784703] Update Tracker - [Pathway:975871] MyD88 cascade initiated on plasma membrane - v53:[updateContainedPathway]
[UpdateTracker:9784575] Update Tracker - [Reaction:216727] 4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 - v53:[add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9784740] Update Tracker - [Pathway:186797] Signaling by PDGF - v53:[updateContainedPathway]
[UpdateTracker:9784652] Update Tracker - [Pathway:5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - v53:[updateContainedRLE]
[UpdateTracker:9784584] Update Tracker - [Pathway:75893] TNF signaling - v53:[modifyText, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784559] Update Tracker - [Reaction:548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA - v53:[modifyText]
[UpdateTracker:9784715] Update Tracker - [Pathway:380972] Energy dependent regulation of mTOR by LKB1-AMPK - v53:[add_removeHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9784570] Update Tracker - [Reaction:109822] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 - v53:[add_removeOutput, modifyText, removeInput]
[UpdateTracker:9784756] Update Tracker - [Reaction:2029989] Autocatalytic phosphorylation of overexpressed FGFR2 variants - v53:[modifyText]
[UpdateTracker:9784689] Update Tracker - [Reaction:74715] Autophosphorylation of insulin receptor - v53:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9784611] Update Tracker - [Reaction:917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - v53:[add_removeOutput, modifyText]
[UpdateTracker:9784766] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v53:[addHasEvent, addLiteratureReference]
[UpdateTracker:9784582] Update Tracker - [Reaction:380927] p-AMPK phosphorylates TSC1:TSC2 - v53:[modifyText]
[UpdateTracker:9784755] Update Tracker - [Pathway:76042] RNA Polymerase II Transcription Initiation And Promoter Clearance - v53:[updateIndirectRLE]
[UpdateTracker:9784773] Update Tracker - [Pathway:5654693] FRS-mediated FGFR1 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784622] Update Tracker - [Pathway:205017] NFG and proNGF binds to p75NTR - v53:[updateContainedRLE]
[UpdateTracker:9784579] Update Tracker - [Pathway:5654696] Downstream signaling of activated FGFR2 - v53:[updateContainedPathway]
[UpdateTracker:9784749] Update Tracker - [Reaction:176956] Formation of GINS complex - v53:[add_removeInput]
[UpdateTracker:9784684] Update Tracker - [Pathway:2428924] IGF1R signaling cascade - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784735] Update Tracker - [Reaction:382575] ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix - v53:[modifyText]
[UpdateTracker:9784851] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v53:[addHasEvent]
[UpdateTracker:9784704] Update Tracker - [Pathway:187687] Signalling to ERKs - v53:[updateContainedPathway]
[UpdateTracker:9784720] Update Tracker - [Reaction:2730887] Autophosphorylation and activation of MEKK1 - v53:[add_removeRegulator]
[UpdateTracker:9784571] Update Tracker - [Pathway:2428933] SHC-related events triggered by IGF1R - v53:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9784853] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v53:[modifyText]
[UpdateTracker:9784825] Update Tracker - [Pathway:445144] Signal transduction by L1 - v53:[updateContainedRLE]
[UpdateTracker:9784699] Update Tracker - [Pathway:69190] DNA strand elongation - v53:[updateIndirectRLE]
[UpdateTracker:9784793] Update Tracker - [Pathway:170968] Frs2-mediated activation - v53:[add_removeHasEvent]
[UpdateTracker:9784558] Update Tracker - [Pathway:70895] Branched-chain amino acid catabolism - v53:[updateContainedRLE]
[UpdateTracker:9784649] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway, updateContainedRLE]
[UpdateTracker:9784738] Update Tracker - [Pathway:446210] Synthesis of UDP-N-acetyl-glucosamine - v53:[updateContainedRLE]
[UpdateTracker:9784818] Update Tracker - [Pathway:170984] ARMS-mediated activation - v53:[add_removeHasEvent]
[UpdateTracker:9784587] Update Tracker - [Reaction:77073] SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) - v53:[modifyText]
[UpdateTracker:9784711] Update Tracker - [Reaction:112377] Grb2:Sos2:p-Y-Irs1 mediated nucleotide exchange of p21 Ras (IRS) - v53:[modifyText]
[UpdateTracker:9784665] Update Tracker - [Pathway:1430728] Metabolism - v53:[updateContainedPathway]
[UpdateTracker:9784616] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v53:[addHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784629] Update Tracker - [Reaction:74746] GRB2-1:SOS1 binds p-Y427-SHC1 - v53:[add_removeInput, modifyText]
[UpdateTracker:9784748] Update Tracker - [Pathway:168249] Innate Immune System - v53:[updateContainedPathway]
[UpdateTracker:9784819] Update Tracker - [Pathway:2404192] Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) - v53:[updateContainedPathway]
[UpdateTracker:9784751] Update Tracker - [Pathway:187037] Signaling by NTRK1 (TRKA) - v53:[updateContainedPathway]
[UpdateTracker:9784555] Update Tracker - [Pathway:194138] Signaling by VEGF - v53:[updateContainedPathway]
[UpdateTracker:9784813] Update Tracker - [Pathway:372708] p130Cas linkage to MAPK signaling for integrins - v53:[addLiteratureReference, updateContainedRLE]
[UpdateTracker:9784820] Update Tracker - [Pathway:5578749] Transcriptional regulation by small RNAs - v53:[updateContainedRLE]
[UpdateTracker:9784701] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v53:[modifyText]
[UpdateTracker:9784747] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784769] Update Tracker - [Reaction:5358592] DNA ligase I ligates single stranded nick in double stranded DNA - v53:[add_removeCatalystActivity]
[UpdateTracker:9784779] Update Tracker - [Reaction:3371385] TNF-alpha is cleaved by ADAM17 (TACE) - v53:[modifyText]
[UpdateTracker:9784612] Update Tracker - [Pathway:5655291] Signaling by FGFR4 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway]
[UpdateTracker:9784732] Update Tracker - [Reaction:1369028] ABCAs mediate lipid efflux - v53:[modifyText, removeLiteratureReference]
[UpdateTracker:9784671] Update Tracker - [Pathway:194002] Glucocorticoid biosynthesis - v53:[updateContainedRLE]
[UpdateTracker:9784695] Update Tracker - [Pathway:450294] MAP kinase activation - v53:[add_removeHasEvent]
[UpdateTracker:9784823] Update Tracker - [Pathway:5358508] Mismatch Repair - v53:[updateIndirectRLE]
[UpdateTracker:9784728] Update Tracker - [Reaction:216757] 4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane - v53:[modifyText]
[UpdateTracker:9784602] Update Tracker - [Reaction:447074] AMPK phosphorylates Raptor in the mTORC1 complex - v53:[add_removeOutput]
[UpdateTracker:9784685] Update Tracker - [Pathway:2424491] DAP12 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784618] Update Tracker - [Pathway:5654706] FRS-mediated FGFR3 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784581] Update Tracker - [Pathway:1839122] Signaling by activated point mutants of FGFR1 - v53:[modifyText]
[UpdateTracker:9784833] Update Tracker - [Pathway:2586552] Signaling by Leptin - v53:[add_removeHasEvent]
[UpdateTracker:9784731] Update Tracker - [Reaction:165726] Phosphorylation of Ribosomal protein S6 by activated S6K1 - v53:[modifyText]
[UpdateTracker:9784727] Update Tracker - [Pathway:3238698] WNT ligand biogenesis and trafficking - v53:[addHasEvent]
[UpdateTracker:9784639] Update Tracker - [Reaction:69891] Phosphorylation and activation of CHEK2 by ATM - v53:[addLiteratureReference, addOutput, add_removeCatalystActivity, add_removeInput, modifyText]
[UpdateTracker:9784845] Update Tracker - [Pathway:166208] mTORC1-mediated signalling - v53:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9784792] Update Tracker - [Pathway:110056] MAPK3 (ERK1) activation - v53:[modifyText, removeHasEvent, updateContainedRLE]
[UpdateTracker:9784645] Update Tracker - [Pathway:5675482] Regulation of necroptotic cell death - v53:[updateIndirectRLE]
[UpdateTracker:9784763] Update Tracker - [Pathway:382551] Transport of small molecules - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784651] Update Tracker - [Reaction:216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane - v53:[modifyText]
[UpdateTracker:9784718] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v53:[updateContainedRLE]
[UpdateTracker:9784794] Update Tracker - [Pathway:917937] Iron uptake and transport - v53:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784561] Update Tracker - [Pathway:1839128] FGFR4 mutant receptor activation - v53:[add_removeSummation, removeLiteratureReference]
[UpdateTracker:9784564] Update Tracker - [Reaction:109807] GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS - v53:[modifyText]
[UpdateTracker:9784646] Update Tracker - [Reaction:74743] Dissociation of p-Y427-SHC1 from insulin receptor - v53:[add_removeSummation]
[UpdateTracker:9784836] Update Tracker - [Pathway:69481] G2/M Checkpoints - v53:[updateIndirectRLE]
[UpdateTracker:9784657] Update Tracker - [Reaction:1839094] Activated FGFR1 mutants and fusions bind PLCG1 - v53:[addLiteratureReference, add_removeInput, modifyText]
[UpdateTracker:9784696] Update Tracker - [Pathway:73887] Death Receptor Signalling - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784599] Update Tracker - [Pathway:5654741] Signaling by FGFR3 - v53:[updateContainedPathway]
[UpdateTracker:9784668] Update Tracker - [Pathway:74749] Signal attenuation - v53:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9784746] Update Tracker - [Reaction:74747] Dephosphorylation of p-Y-IRS1,p-Y-IRS2 - v53:[add_removeInput]
[UpdateTracker:9784631] Update Tracker - [Reaction:109862] MAP2K2 phosphorylates MAPK1 - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784666] Update Tracker - [Pathway:74713] IRS activation - v53:[modifyText, updateContainedRLE]
[UpdateTracker:9784680] Update Tracker - [Reaction:164834] Enzyme-bound ATP is released - v53:[modifyText]
[UpdateTracker:9784626] Update Tracker - [Reaction:165692] Phosphorylation of 4E-BP1 by activated mTORC1 - v53:[add_removeSummation]
[UpdateTracker:9784808] Update Tracker - [Reaction:74740] Binding of SHC1 to insulin receptor - v53:[add_removeSummation]
[UpdateTracker:9784637] Update Tracker - [Pathway:1839117] Signaling by cytosolic FGFR1 fusion mutants - v53:[removeHasEvent]
[UpdateTracker:9784803] Update Tracker - [Reaction:163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 - v53:[modifyText]
[UpdateTracker:9784736] Update Tracker - [Pathway:163125] Post-translational modification: synthesis of GPI-anchored proteins - v53:[updateIndirectRLE]
[UpdateTracker:9784607] Update Tracker - [Pathway:372790] Signaling by GPCR - v53:[updateContainedPathway]
[UpdateTracker:9784834] Update Tracker - [Pathway:5654712] FRS-mediated FGFR4 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784759] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v53:[updateContainedPathway]
[UpdateTracker:9784826] Update Tracker - [Pathway:159236] Transport of Mature mRNA derived from an Intron-Containing Transcript - v53:[updateContainedRLE]
[UpdateTracker:9784781] Update Tracker - [Pathway:5654700] FRS-mediated FGFR2 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784624] Update Tracker - [Pathway:5663084] Diseases of carbohydrate metabolism - v53:[updateContainedPathway]
[UpdateTracker:9784547] Update Tracker - [Pathway:372442] Lipid metabolism - v53:[updateIndirectRLE]
[UpdateTracker:9784801] Update Tracker - [Pathway:5654736] Signaling by FGFR1 - v53:[updateContainedPathway]
[UpdateTracker:9784647] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v53:[modifyText]
[UpdateTracker:9784643] Update Tracker - [Pathway:5357786] TNFR1-induced proapoptotic signaling - v53:[updateContainedRLE]
[UpdateTracker:9784688] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v53:[updateContainedPathway]
[UpdateTracker:9784572] Update Tracker - [Pathway:5218900] CASP8 activity is inhibited - v53:[updateContainedRLE]
[UpdateTracker:9784670] Update Tracker - [Pathway:76009] Platelet Aggregation (Plug Formation) - v53:[updateContainedPathway]
[UpdateTracker:9784772] Update Tracker - [Reaction:164515] Fusogenic activation of gp41 - v53:[modifyText]
[UpdateTracker:9784832] Update Tracker - [Reaction:74742] Phosphorylation of SHC1 - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784697] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v53:[updateContainedRLE]
[UpdateTracker:9784606] Update Tracker - [Pathway:168179] Toll Like Receptor TLR1:TLR2 Cascade - v53:[updateContainedPathway]
[UpdateTracker:9784742] Update Tracker - [Pathway:2033514] FGFR3 mutant receptor activation - v53:[add_removeLiteratureReference, add_removeSummation]
[UpdateTracker:9784760] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v53:[updateContainedPathway]
[UpdateTracker:9784588] Update Tracker - [Pathway:73776] RNA Polymerase II Promoter Escape - v53:[updateContainedRLE]
[UpdateTracker:9784673] Update Tracker - [Pathway:433584] Sphingolipid metabolism - v53:[updateContainedRLE]
[UpdateTracker:9784654] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v53:[modifyText]
[UpdateTracker:9784723] Update Tracker - [Pathway:2682334] EPH-Ephrin signaling - v53:[updateIndirectRLE]
[UpdateTracker:9784782] Update Tracker - [Reaction:2672196] Viral serpin blocks caspase-8 activity - v53:[modifyText]
[UpdateTracker:9784761] Update Tracker - [Pathway:195721] Signaling by WNT - v53:[updateContainedPathway]
[UpdateTracker:9784692] Update Tracker - [Reaction:165195] GTP loading by Rheb - v53:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9784743] Update Tracker - [Pathway:5655332] Signaling by FGFR3 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway]
[UpdateTracker:9784563] Update Tracker - [Pathway:190377] FGFR2b ligand binding and activation - v53:[addHasEvent]
[UpdateTracker:9784753] Update Tracker - [Pathway:169893] Prolonged ERK activation events - v53:[updateContainedPathway]
[UpdateTracker:9784822] Update Tracker - [Pathway:2428928] IRS-related events triggered by IGF1R - v53:[updateContainedPathway]
[UpdateTracker:9784843] Update Tracker - [Pathway:173107] Binding and entry of HIV virion - v53:[updateContainedRLE]
[UpdateTracker:9784619] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v53:[updateContainedRLE]
[UpdateTracker:9784554] Update Tracker - [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - v53:[modifyText]
[UpdateTracker:9784785] Update Tracker - [Pathway:2023837] Signaling by FGFR2 amplification mutants - v53:[updateContainedRLE]
[UpdateTracker:9784707] Update Tracker - [Reaction:167153] SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) - v53:[modifyText]
[UpdateTracker:9784658] Update Tracker - [Reaction:1562626] Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) - v53:[add_removeOutput, modifyText]
[UpdateTracker:9784682] Update Tracker - [Reaction:983709] LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) - v53:[addRegulator]
[UpdateTracker:9784573] Update Tracker - [Reaction:372693] Phosphorylation of BCAR1 by SRC-PTK2 complex - v53:[addLiteratureReference]
[UpdateTracker:9784677] Update Tracker - [BlackBoxEvent:167113] Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition - v53:[modifyText]
[UpdateTracker:9784679] Update Tracker - [Pathway:179812] GRB2 events in EGFR signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784574] Update Tracker - [Reaction:5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) - v53:[modifyText]
[UpdateTracker:9784630] Update Tracker - [Pathway:74752] Signaling by Insulin receptor - v53:[addLiteratureReference, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784603] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v53:[updateContainedRLE]
[UpdateTracker:9784700] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v53:[updateContainedPathway]
[UpdateTracker:9784546] Update Tracker - [Pathway:5654687] Downstream signaling of activated FGFR1 - v53:[updateContainedPathway]
[UpdateTracker:9784605] Update Tracker - [Pathway:75876] Synthesis of very long-chain fatty acyl-CoAs - v53:[updateContainedRLE]
[UpdateTracker:9784771] Update Tracker - [Reaction:74707] Binding of IRS to insulin receptor - v53:[modifyText]
[UpdateTracker:9784694] Update Tracker - [Reaction:917987] TFRC dimer binds 2xholoTF - v53:[modifyText]
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