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Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus Show undefined attributes

author

[Person:9682822] Li, FQ
[Person:8862557] Xiao, H
[Person:9682931] Tam, JP
[Person:9682840] Liu, DX

created [InstanceEdit:9683039] Stephan, Ralf, 2020年04月14日

dbId 9682825

displayName Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus

journal FEBS Lett.

pages 2387-96

pubMedIdentifier 15848177

schemaClass LiteratureReference

title Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus

url http://www.ncbi.nlm.nih.gov/pubmed/15848177

volume 579

year 2005

Referrals

(literatureReference)

[Summation:9694530] This COVID-19 pathway has been created by a combination of c...
[Pathway:R-HSA-9694631] Maturation of nucleoprotein
[Summation:9694589] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

A certain part of the nucleoprotein can be found in the nucleolus. This localisation seems to depend on the protein's sumoylation (Li et al, 2005)
[BlackBoxEvent:R-HSA-9694345] Nucleoprotein translocates to the nucleolus
[Summation:9682835] Nucleoprotein, the most abundant viral protein expressed dur...
[Pathway:R-HSA-9683610] Maturation of nucleoprotein
[EntityWithAccessionedSequence:R-COV-9686063] SUMO1-K62-ADPr-p-S177-N [plasma membrane]
[EntityWithAccessionedSequence:R-COV-9729325] SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
[Summation:9683080] A certain part of the nucleoprotein can be found in the nucl...
[BlackBoxEvent:R-HSA-9683606] Nucleoprotein translocates to the nucleolus
[EntityWithAccessionedSequence:R-COV-9683730] SUMO1-K62-ADPr-p-S177-N [nucleolus]
[EntityWithAccessionedSequence:R-COV-9729339] SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
[Summation:9682781] Nucleoprotein is capable of homodimerization in a mammalian ...
[EntityWithAccessionedSequence:R-COV-9683641] SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
[EntityWithAccessionedSequence:R-COV-9685478] SUMO1-K62-ADPr-p-S177-N [viral capsid]
[Summation:9694340] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

N protein is sumoylated at a lysine residue. Abolition of sumoylation of nucleoprotein significantly decreases homo-oligomerisation of the protein (Li et al, 2005)
[Reaction:R-HSA-9729307] Nucleoprotein is SUMOylated
[Summation:9682947] Lysine-62 is the major sumoylation site of N protein. Abolit...
[Reaction:R-HSA-9683687] Nucleoprotein is SUMOylated
[EntityWithAccessionedSequence:R-COV-9682916] SUMO1-K62-ADPr-p-S177-N [cytosol]
[Summation:9682867] Open reading frame 9a (ORF9a) of SARS-CoV-1 mRNA9 has a leng...
[EntityWithAccessionedSequence:R-COV-9729341] SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
[EntityWithAccessionedSequence:R-COV-9729340] SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]

(author)

[Person:9682840] Liu, DX
[Person:8862557] Xiao, H
[Person:9682822] Li, FQ
[Person:9682931] Tam, JP

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