Reactome Pathway Database

Benzoate and ATP react with coenzyme A to form benzoyl CoA, ... Show undefined attributes

created [InstanceEdit:177120] D'Eustachio, P, 2006年03月23日 20:05:02

dbId 177156

displayName Benzoate and ATP react with coenzyme A to form benzoyl CoA, ...

literatureReference

[LiteratureReference:159570] Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids
[LiteratureReference:159552] Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria
[LiteratureReference:177141] Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product

schemaClass Summation

text Benzoate and ATP react with coenzyme A to form benzoyl CoA, AMP, and pyrophosphate (Vessey et al. 1999, 2003). Two human CoA ligases have been characterized that catalyze this reaction efficiently in vitro: acyl-CoA synthetase medium-chain family member 1 (BUCS1) (Fujino et al. 2001) and xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Their relative contributions to benzoate metabolism in vivo are unknown.

Referrals

(summation)

[Reaction:R-HSA-159443] benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate

Cite Us!