RN-9893
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Chemical compound
Pharmaceutical compound
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| Formula | C21H23F3N4O5S |
| Molar mass | 500.49 g·mol−1 |
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RN-9893 is a drug which acts as a potent and selective blocker of the TRPV4 ion channel. It has been used to investigate the role of TRPV4 channels in the function of heart valves.[1] [2]
See also
[edit ]References
[edit ]- ^ Wei ZL, Nguyen MT, O'Mahony DJ, Acevedo A, Zipfel S, Zhang Q, et al. (September 2015). "Identification of orally-bioavailable antagonists of the TRPV4 ion-channel". Bioorganic & Medicinal Chemistry Letters. 25 (18): 4011–5. doi:10.1016/j.bmcl.2015年06月09日8. PMID 26235950.
- ^ Al-Shammari H, Latif N, Sarathchandra P, McCormack A, Rog-Zielinska EA, Raja S, et al. (2020). "Expression and function of mechanosensitive ion channels in human valve interstitial cells". PLOS ONE. 15 (10) e0240532. Bibcode:2020PLoSO..1540532A. doi:10.1371/journal.pone.0240532 . PMC 7561104 . PMID 33057457.
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