File:Positive allosteric modulator plot.svg

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Summary

DescriptionPositive allosteric modulator plot.svg

English: Positive allosteric modulators (PAMs) move agonist dose-response curves to lower agonist concentrations by increasing agonist affinity and/or increase maximal response by increasing agonist efficacy.

Plot shows receptor response (%) as a function of logarithmic agonist concentration ([Ago]). This is just an example and the units of concentration do not matter. Solid curve: original agonist response. Dashed curves: 2 possible response curves (out of many alternatives) after PAM addition. Arrows show approximate direction of the shift of curves after addition.

Adapted from:

Kenakin TP (2017). Pharmacology in drug discovery and development: understanding drug response (2nd ed.). Academic Press. pp. 109–110. ISBN 9780128037539.

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The person who associated a work with this deed has dedicated the work to the public domain by waiving all of their rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission.

http://creativecommons.org/publicdomain/zero/1.0/deed.enCC0Creative Commons Zero, Public Domain Dedicationfalsefalse

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Allosteric modulator

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Usage on fi.wikipedia.org
- Allosteerinen säätelijä
Usage on ja.wikipedia.org
- アロステリック調節因子
Usage on ru.wikipedia.org
- Аллостерический модулятор

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