Metabolic, drug-induced, and other noninflammatory myopathies

Rheumatology (Sixth Edition)

Volume 2, 2015, Pages 1255-1263

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Metabolic tricks of cancer cells
2022, Biochimica Et Biophysica Acta Reviews on Cancer
Citation Excerpt :
Glycolysis is a very inefficient method of ATP production, as only 2 ATP molecules are formed. On the contrary, it is approximately 100 times faster than aerobic respiration [42]. Cells using Warburg effect obtain most of their ATP through glycolysis, even if they have enough oxygen and consequently, the formation of ATP by OXPHOS is significantly suppressed.
One of the characteristics of cancer cells important for tumorigenesis is their metabolic plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic pathways to support the increased energy request due to continuous growth and rapid proliferation. Moreover, selective pressures in the tumor microenvironment, such as hypoxia, acidosis, and competition for resources, force cancer cells to adapt by complete reorganization of their metabolism. In this review, we highlight the characteristics of cancer metabolism and discuss its clinical significance, since overcoming metabolic plasticity of cancer cells is a key objective of modern cancer therapeutics and a better understanding of metabolic reprogramming may lead to the identification of possible targets for cancer therapy.
The dynamic computer workstation—a pilot study of clinical and biochemical investigation during work at static respectively mobile keyboards
2021, International Journal of Environmental Research and Public Health