Example search terms: loss of pathogenicity, Candida, Enterococcus, Magnaporthe oryzae, wheat, azole, spot blotch disease, PHI:1020, ABC1, anti-infective. Type * to browse database.

From mutant genes to phenotypes! The mission of PHI-base is to provide expertly curated molecular and biological information on genes proven to affect the outcome of pathogen-host interactions. Information is also given on the target sites of some anti-infective chemistries.

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PHIB-BLAST
Find homologs and their phenotypes

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Manual curation of the pathogen interaction literature

How to cite us:
Urban, M. et al (2025). NAR. doi: 10.1093/nar/gkae1084

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PHI spotlight

We recently announced the launch of PHI-base 5, the new gene-centric version of PHI-base, through a press release on the Rothamsted Research website. A summary of the improvements made is also available.

This version allows the display of diverse phenotypes and many additional data curated with our community curation interface, called PHI-Canto.

PHI-base 4 will remain online until end of 2025. Please use this version to download complete datasets.

The PHI-Canto community interspecies curation tool and framework description is available here: Cuzick et al, 2023, doi 10.7554/ eLife.84658.
A short overview is provided in an associated eLife digest.

Version: 4.18 release - Last revision: 01/05/2025

PHI-base is funded by the Biotechnology and Biological Sciences Research Council (BBSRC, UK) and is being developed and maintained by scientists at Rothamsted Research.
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