Bioinformatics Tutorial

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University of Illinois at Urbana-Champaign
Department of Chemistry, Luthey-Schulten Group
Beckman Institute for Advanced Science and Technology
Theoretical and Computational Biophysics Group
Summer School 2003

Bioinformatics, Sequence and Structural Alignment

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Felix Autenrieth

Barry Isralewitz

Zaida Luthey-Schulten

Anurag Sethi

Taras Pogorelov

June 2003

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Introduction
- To set up the exercises...
Biology of class II aminoacyl-tRNA Synthetases
AARSs in Methanococcus jannaschii
Domain structure of class II tRNA synthetases
SCOP fold classification
Sequence Alignment Algorithms
- Manually perform a Needleman-Wunsch alignment
- Finding homologous pairs of ClassII tRNA synthetases
Sequence and structural alignments in MOE
Viewing conserved domains of AARSs
Molecular phylogenetic tree.
Other bioinformatics tools
Bibliography

zan@uiuc.edu