S1pr2 MGI Mouse Gene Detail - MGI:99569 - sphingosine-1-phosphate receptor 2

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S1pr2 Gene Detail
Summary
  • Symbol
    S1pr2
  • Name
    sphingosine-1-phosphate receptor 2
  • Synonyms
    1100001A16Rik, Edg5, Gpcr13, H218, LPb2, S1P2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99569
    NCBI Gene: 14739
  • Alliance
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr9:20877248-20888089 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.68 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99569
protein coding gene Chr9:20873657-20888089 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034433
protein coding gene Chr9:18134523-18147266 (-)
A/J MGP_AJ_G0034411
protein coding gene Chr9:17841904-17852814 (-)
AKR/J MGP_AKRJ_G0034338
protein coding gene Chr9:18160937-18171778 (-)
BALB/cJ MGP_BALBcJ_G0034402
protein coding gene Chr9:17738254-17749085 (-)
C3H/HeJ MGP_C3HHeJ_G0034114
protein coding gene Chr9:18472205-18483465 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034923
protein coding gene Chr9:18862929-18873678 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031853
protein coding gene Chr9:16966304-16977171 (-)
CAST/EiJ MGP_CASTEiJ_G0033437
protein coding gene Chr9:18299527-18312750 (-)
CBA/J MGP_CBAJ_G0034087
protein coding gene Chr9:19580691-19591529 (-)
DBA/2J MGP_DBA2J_G0034246
protein coding gene Chr9:17825372-17836145 (-)
FVB/NJ MGP_FVBNJ_G0034189
protein coding gene Chr9:17331512-17342953 (-)
LP/J MGP_LPJ_G0034331
protein coding gene Chr9:18316236-18327076 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034232
protein coding gene Chr9:21201209-21212066 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034943
protein coding gene Chr9:18116857-18127605 (-)
PWK/PhJ MGP_PWKPhJ_G0033143
protein coding gene Chr9:17791509-17802403 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032977
protein coding gene Chr9:18162057-18172859 (-)
WSB/EiJ MGP_WSBEiJ_G0033552
protein coding gene Chr9:17844545-17855197 (-)



Homology
more
  • Human Ortholog
    S1PR2, sphingosine-1-phosphate receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    S1PR2, sphingosine-1-phosphate receptor 2
  • Synonyms
    AGR16, DFNB68, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2
  • Links
    NCBI Gene ID: 9294
    UniProt: O95136

  • Chr Location
    19p13.2; chr19:10221433-10231331 (-) GRCh38
Human Diseases
more
  • Diseases
    2 with S1pr2 mouse models; 1 with human S1PR2 associations

Human Disease Mouse Models
IDs
autosomal recessive nonsyndromic deafness 68

DOID:0110519
ICD10CM:H90.3
OMIM:610419

View 2 models
Mouse Models

Human Disease Modeled: autosomal recessive nonsyndromic deafness 68

Allelic Composition Genetic Background Reference Phenotypes
S1pr2stdf/S1pr2stdf
involves: C57BL/6Brd * C57BL/6N J:240361 View
S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6) J:231927 View
IDs
non-Hodgkin lymphoma

DOID:0060060
ICD10CM:C85.9
MESH:D008228
NCI:C3211
OMIM:605027
ORDO:547
UMLS_CUI:C0024305

 View 2 models
Mouse Models

Human Disease Modeled: non-Hodgkin lymphoma

Allelic Composition Genetic Background Reference Phenotypes
S1pr2tm1Ajml/S1pr2tm1Ajml
129S5/SvEvBrd-S1pr2tm1Ajml J:154439 View
S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6 J:154439 View
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 7 alleles in 9 genetic backgrounds
    30 phenotypes from multigenic genotypes
    8 images
    87 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations in this gene may lead to impaired auditory and vestibular function, multiple inner ear pathologies, deafness, altered neuronal excitability, lethal seizures, altered physiology of germinal center B cells, small litter size, and enhanced tumor angiogenesis and tumor growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14739 NCBI Gene Model | MGI Sequence Detail 10842 C57BL/6J ± kb
    transcript NM_010333 RefSeq | MGI Sequence Detail 2815 ZRU/MplStud
    polypeptide P52592 UniProt | EBI | MGI Sequence Detail 352 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 94
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16349, MGI:1915680
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 24
      Diseases 3
      Gene Ontology 15
      Phenotypes 87
    • Earliest
      J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
    • Latest
      J:357471 Pagella P, et al., An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation. Int J Oral Sci. 2024;16(1):60
    TSS for S1pr2:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr88349 Chr9:20888058-20888070 (-) 25 bp
    Tssr88348 Chr9:20888017-20888044 (-) 58 bp
    Tssr88347 Chr9:20887967-20888015 (-) 98 bp
    S1pr2 is Candidate Gene for:
    QTL Genetic Location* Genome Location (GRCm39) Reference QTL Note
    Ap5q Chr9, 25.70 cM Chr9:47053164-47053277 J:98595 Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. These candidate genes are Edg5 (6 cM), Anln, Hspa8 (24 cM), Phldb1, Zbtb16 (23 cM), Rab7 (38.5 cM), Psma4, and Rplp1.
    *cM position of peak correlated region/marker
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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