Tbxa2r MGI Mouse Gene Detail - MGI:98496 - thromboxane A2 receptor

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Tbxa2r Gene Detail
Summary
  • Symbol
    Tbxa2r
  • Name
    thromboxane A2 receptor
  • Synonyms
    TP, Tp receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:98496
    NCBI Gene: 21390
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81164565-81171006 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98496
protein coding gene Chr10:81164102-81171008 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017551
protein coding gene Chr10:82041124-82047777 (+)
A/J MGP_AJ_G0017529
protein coding gene Chr10:79132357-79138737 (+)
AKR/J MGP_AKRJ_G0017490
protein coding gene Chr10:81305872-81313823 (+)
BALB/cJ MGP_BALBcJ_G0017491
protein coding gene Chr10:79351972-79358874 (+)
C3H/HeJ MGP_C3HHeJ_G0017314
protein coding gene Chr10:81405799-81413222 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017945
protein coding gene Chr10:84857173-84864766 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015634
protein coding gene Chr10:75329336-75335640 (+)
CAST/EiJ MGP_CASTEiJ_G0016881
protein coding gene Chr10:81635083-81641541 (+)
CBA/J MGP_CBAJ_G0017286
protein coding gene Chr10:88164808-88174659 (+)
DBA/2J MGP_DBA2J_G0017392
protein coding gene Chr10:78337266-78343684 (+)
FVB/NJ MGP_FVBNJ_G0017386
protein coding gene Chr10:77585726-77593102 (+)
LP/J MGP_LPJ_G0017463
protein coding gene Chr10:82488337-82494649 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017412
protein coding gene Chr10:90011269-90018578 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017986
protein coding gene Chr10:81315489-81322681 (+)
PWK/PhJ MGP_PWKPhJ_G0016662
protein coding gene Chr10:78230381-78237586 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016452
protein coding gene Chr10:80257642-80266143 (+)
WSB/EiJ MGP_WSBEiJ_G0016941
protein coding gene Chr10:81342824-81351435 (+)



Homology
more
  • Human Ortholog
    TBXA2R, thromboxane A2 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBXA2R, thromboxane A2 receptor
  • Synonyms
    BDPLT13, TXA2-R
  • Links
    NCBI Gene ID: 6915
    UniProt: P21731

  • Chr Location
    19p13.3; chr19:3594507-3606875 (-) GRCh38
Human Diseases
more
  • Diseases
    3 with human TBXA2R associations

Human Disease Mouse Models
IDs
aspirin-induced respiratory disease
IDs
asthma

DOID:2841
DOID:12703
DOID:13829
DOID:13830
DOID:2840
DOID:5783
ICD10CM:J45
ICD9CM:493
ICD9CM:493.9
KEGG:05310
MESH:D001249
NCI:C28397
OMIM:600807
UMLS_CUI:C0004096
IDs
blood platelet disease

DOID:2218
MESH:D001791
NCI:C131634
UMLS_CUI:C0005818
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    60 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show prolonged bleeding, and altered platelet aggregation and vascular responses to TXA2, arachidonic acid and injury. Homozygotes for another null allele show splenomegaly, reduced DC-T cell adhesion, enhanced contact hypersensitivity, and cervical lymphadenopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
    2
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034881 Ensembl Gene Model | MGI Sequence Detail 6442 C57BL/6J ± kb
    transcript ENSMUST00000220312 Ensembl | MGI Sequence Detail 1919 Not Applicable
    polypeptide ENSMUSP00000151447 Ensembl | MGI Sequence Detail 341 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14733
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 60
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:366884 Yang J, et al., Aspirin prevents metastasis by limiting platelet TXA(2) suppression of T cell immunity. Nature. 2025 Apr;640(8060):1052-1061
    TSS for Tbxa2r:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr94739 Chr10:81164520-81164538 (+) -36 bp
    Tssr94740 Chr10:81164553-81164573 (+) -2 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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