Pgr MGI Mouse Gene Detail - MGI:97567 - progesterone receptor

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Pgr Gene Detail
Summary
  • Symbol
    Pgr
  • Name
    progesterone receptor
  • Synonyms
    9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:97567
    NCBI Gene: 18667
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:8899834-8968612 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2212 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97567
protein coding gene Chr9:8890017-8968612 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034336
protein coding gene Chr9:5771465-5841866 (+)
A/J MGP_AJ_G0034314
protein coding gene Chr9:5904557-5976150 (+)
AKR/J MGP_AKRJ_G0034242
protein coding gene Chr9:5722665-5793688 (+)
BALB/cJ MGP_BALBcJ_G0034308
protein coding gene Chr9:5615211-5683807 (+)
C3H/HeJ MGP_C3HHeJ_G0034019
protein coding gene Chr9:5960568-6034186 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034830
protein coding gene Chr9:5979458-6053361 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031768
protein coding gene Chr9:5028358-5095638 (+)
CAST/EiJ MGP_CASTEiJ_G0033347
protein coding gene Chr9:5896258-5968804 (+)
CBA/J MGP_CBAJ_G0033992
protein coding gene Chr9:6230540-6311129 (+)
DBA/2J MGP_DBA2J_G0034149
protein coding gene Chr9:5748934-5820994 (+)
FVB/NJ MGP_FVBNJ_G0034094
protein coding gene Chr9:5489469-5558171 (+)
LP/J MGP_LPJ_G0034235
protein coding gene Chr9:5785691-5856397 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034138
protein coding gene Chr9:6912063-6984656 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034849
protein coding gene Chr9:5737221-5807397 (+)
PWK/PhJ MGP_PWKPhJ_G0033050
protein coding gene Chr9:5814749-5888033 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032888
protein coding gene Chr9:5930149-6003059 (+)
WSB/EiJ MGP_WSBEiJ_G0033462
protein coding gene Chr9:5726283-5797863 (+)



Homology
more
  • Human Ortholog
    PGR, progesterone receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGR, progesterone receptor
  • Synonyms
    NR3C3, PR
  • Links
    NCBI Gene ID: 5241
    UniProt: P06401

  • Chr Location
    11q22.1; chr11:101029624-101129813 (-) GRCh38
Human Diseases
more
  • Diseases
    3 with human PGR associations

Human Disease Mouse Models
IDs
endometriosis

DOID:289
EFO:0001065
ICD10CM:N80
ICD9CM:617
ICD9CM:617.9
MESH:D004715
NCI:C3014
UMLS_CUI:C0014175

 View 1 model
Mouse Models

Human Disease Modeled: endometriosis

Allelic Composition Genetic Background Reference Phenotypes
Hdac3tm1.1Eno/Hdac3tm1.1Eno
Pgrtm2(cre)Lyd/Pgr+
 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 J:269518 View
IDs
hyperprolactinemia

DOID:12700
DOID:12699
ICD10CM:E22.1
MESH:D002640
MESH:D006966
UMLS_CUI:C0008043
UMLS_CUI:C0020514
IDs
obesity

DOID:9970
EFO:0001073
ICD10CM:E66.9
ICD9CM:278.00
MESH:D009765
NCI:C159658
OMIM:601665
UMLS_CUI:C0028754
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 10 alleles in 10 genetic backgrounds
    83 phenotypes from multigenic genotypes
    3 images
    366 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null female mice are sterile and exhibit ovulatory defects, uterine hyperplasia, and impaired mammary development. Females lacking only isoform A are infertile but show normal mammary development, while females lacking only isoform B are fertile but present with mammary developmental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031870 Ensembl Gene Model | MGI Sequence Detail 68779 C57BL/6J ± kb
    transcript ENSMUST00000070463 Ensembl | MGI Sequence Detail 3068 Not Applicable
    polypeptide ENSMUSP00000063562 Ensembl | MGI Sequence Detail 926 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 5
      cDNA 18
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13282, MGI:2143361, MGI:2444097, MGI:3642750
    References
    more
    • Summaries
      All 492
      Developmental Gene Expression 55
      Diseases 6
      Gene Ontology 20
      Phenotypes 366
    • Earliest
      J:12501 Naylor SL, et al., The progesterone receptor gene is on mouse Chromosome 9. Cytogenet Cell Genet. 1989;51:1051 (Abstr.)
    • Latest
      J:373277 Joshi S, et al., Progesterone receptors regulate susceptibility to spreading depression. Exp Neurol. 2025 Mar;385:115139
    TSS for Pgr:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr83789 Chr9:8899829-8899856 (+) 9 bp
    Tssr83790 Chr9:8900410-8900426 (+) 584 bp
    Tssr83791 Chr9:8900460-8900490 (+) 641 bp
    Tssr83792 Chr9:8900491-8900503 (+) 663 bp
    Tssr83793 Chr9:8900564-8900575 (+) 736 bp
    Tssr83794 Chr9:8901536-8901550 (+) 1,709 bp
    Tssr83795 Chr9:8901700-8901785 (+) 1,909 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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