Kitl MGI Mouse Gene Detail - MGI:96974 - kit ligand

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Kitl Gene Detail
Summary
  • Symbol
    Kitl
  • Name
    kit ligand
  • Synonyms
    blz, Gb, grizzle-belly, Kitlg, Mgf, SCF, SF, Sl, SLF, Steel, Steel factor, stem cell factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96974
    NCBI Gene: 17311
  • Alliance
  • Transcription Start Sites
    13 TSS
  • Regulated by
    Rr438282 (1 regulatory region)
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr10:99851492-99936278 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 51.40 cM
  • Mapping Data
    52 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2669 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96974
protein coding gene Chr10:99851477-99936278 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017689
protein coding gene Chr10:101871849-101963601 (+)
A/J MGP_AJ_G0017668
protein coding gene Chr10:98165569-98251097 (+)
AKR/J MGP_AKRJ_G0017628
protein coding gene Chr10:100965612-101054692 (+)
BALB/cJ MGP_BALBcJ_G0017632
protein coding gene Chr10:98476803-98565626 (+)
C3H/HeJ MGP_C3HHeJ_G0017455
protein coding gene Chr10:100997089-101085542 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018088
protein coding gene Chr10:105404476-105502604 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015768
protein coding gene Chr10:93575706-93662258 (+)
CAST/EiJ MGP_CASTEiJ_G0017018
protein coding gene Chr10:101105167-101205619 (+)
CBA/J MGP_CBAJ_G0017424
protein coding gene Chr10:109481447-109582800 (+)
DBA/2J MGP_DBA2J_G0017530
protein coding gene Chr10:97256881-97342991 (+)
FVB/NJ MGP_FVBNJ_G0017523
protein coding gene Chr10:96461120-96547674 (+)
LP/J MGP_LPJ_G0017604
protein coding gene Chr10:102460705-102562922 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017553
protein coding gene Chr10:110756939-110847279 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018126
protein coding gene Chr10:100939138-101032261 (+)
PWK/PhJ MGP_PWKPhJ_G0016800
protein coding gene Chr10:97387232-97473857 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016589
protein coding gene Chr10:99810517-99905138 (+)
WSB/EiJ MGP_WSBEiJ_G0017078
protein coding gene Chr10:100944334-101031327 (+)



Homology
more
  • Human Ortholog
    KITLG, KIT ligand
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KITLG, KIT ligand
  • Synonyms
    DCUA, DFNA69, FPH2, FPHH, Kitl, KL-1, MGF, SCF, SF, SHEP7, SLF, WS2F
  • Links
    NCBI Gene ID: 4254
    UniProt: P21583

  • Chr Location
    12q21.32; chr12:88492793-88580851 (-) GRCh38
Human Diseases
more
  • Diseases
    4 with human KITLG associations

Human Disease Mouse Models
IDs
autosomal dominant nonsyndromic deafness 69

DOID:0110590
ICD10CM:H90.3
OMIM:616697

IDs
familial progressive hyperpigmentation with or without hypopigmentation
IDs
pigmentation disease

DOID:10123
ICD9CM:709.09
UMLS_CUI:C0375489
IDs
Waardenburg syndrome

DOID:9258
MESH:D014849
NCI:C75008
NCI:C85222
OMIM:PS193500
ORDO:3440
ORDO:895
UMLS_CUI:C0079661
UMLS_CUI:C1847800
UMLS_CUI:C3266898
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    96 phenotypes from 54 alleles in 49 genetic backgrounds
    90 phenotypes from multigenic genotypes
    10 images
    255 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene affect migration of embryonic stem cells and cause similar phenotypes to mutations in its receptor gene (Kit). Mutants show mild to severe defects in pigmentation, hemopoiesis and reproduction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019966 Ensembl Gene Model | MGI Sequence Detail 84787 C57BL/6J ± kb
    transcript ENSMUST00000105283 Ensembl | MGI Sequence Detail 5648 Not Applicable
    polypeptide ENSMUSP00000100920 Ensembl | MGI Sequence Detail 273 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 164
      Genomic 12
      cDNA 118
      Primer pair 25
      Other 9

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10006, MGD-MRK-12219, MGD-MRK-14435, MGD-MRK-2018, MGD-MRK-2093, MGI:5304521
    References
    more
    • Summaries
      All 607
      Developmental Gene Expression 127
      Diseases 1
      Gene Ontology 25
      Phenotypes 255
    • Earliest
      J:3399 Sarvella PA, et al., Steel, a new dominant gene in the house mouse: With effects on coat pigment and blood. J Hered. 1956;47(3):123-128
    • Latest
      J:370996 Khouri-Farah N, et al., FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis. Nat Neurosci. 2025 Aug 18;
    Kitl expression regulated by:
    Feature Feature Type Location Reference
    Rr438282, regulatory region 438282 enhancer Chr10:99946979-99947542 J:278149
    TSS for Kitl:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr95553 Chr10:99851679-99851695 (+) 195 bp
    Tssr95554 Chr10:99855146-99855151 (+) 3,657 bp
    Tssr95555 Chr10:99862922-99862939 (+) 11,439 bp
    Tssr95556 Chr10:99873990-99873998 (+) 22,502 bp
    Tssr95557 Chr10:99886712-99886717 (+) 35,223 bp
    Tssr95558 Chr10:99912156-99912160 (+) 60,666 bp
    Tssr95559 Chr10:99932381-99932385 (+) 80,891 bp
    Tssr95560 Chr10:99932885-99932897 (+) 81,399 bp
    Tssr95561 Chr10:99933998-99934016 (+) 82,515 bp
    Tssr95562 Chr10:99934436-99934453 (+) 82,953 bp
    Tssr95563 Chr10:99934926-99934944 (+) 83,443 bp
    Tssr95564 Chr10:99935027-99935044 (+) 83,544 bp
    Tssr95565 Chr10:99935687-99935703 (+) 84,203 bp
    Kitl is Candidate Gene for:
    QTL Genetic Location* Genome Location (GRCm39) Reference QTL Note
    Bgeq8 Chr10, 66.75 cM J:99477 Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
    Igfbp3q2 Chr10, syntenic J:99477 Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
    Insq9 Chr10, 39.72 cM Chr10:82490938-82491121 J:99477 Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
    *cM position of peak correlated region/marker
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
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    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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